Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes. - Wikidata - awgldk - TriplyDB

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.

http://www.wikidata.org/entity/Q34411539

about

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use Regulating the immune system via IL-15 transpresentation Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.IL-15 participates in the respiratory innate immune response to influenza virus infection Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity Increased antitumor effects using IL-2 with anti-TGF-β reveals competition between mouse NK and CD8 T cells.Homeostatic control of memory cell progenitors in the natural killer cell lineage The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment.IL-15, in synergy with RAE-1ɛ, stimulates TCR-independent proliferation and activation of CD8(+) T cells.CD45 Isoform Profile Identifies Natural Killer (NK) Subsets with Differential Activity.Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1 NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model.Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.The host environment is responsible for aging-related functional NK cell deficiency.Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.Functions of IL-15 in anti-viral immunity: multiplicity and variety.The unconventional expression of IL-15 and its role in NK cell homeostasis.Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity.Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs.Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent.Immune System Dysfunction in the Elderly.Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection.Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice.Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers.Engineering monocyte-derived dendritic cells to secrete interferon-α enhances their ability to promote adaptive and innate anti-tumor immune effector functions.Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells.IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients.Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse.Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity.The potential and promise of IL-15 in immuno-oncogenic therapies.An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells.Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect.NK cells of the oldest seniors represent constant and resistant to stimulation high expression of cellular protective proteins SIRT1 and HSP70.ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis.

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Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.

http://www.wikidata.org/entity/Q34411539

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

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Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

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type

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Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

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Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

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Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

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Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

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PNAS.1012128107

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Proceedings of the National Academy of Sciences of the United States of America

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Mature natural killer cells wi ...... h IL-15/IL-15Ralpha complexes.

@en

P2093

Ananda W Goldrath

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Angelique Bellemare-Pelletier

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Kutlu G Elpek

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Mark P Rubinstein

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Shannon J Turley

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P2860

Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

NK cell recognition

Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.

Natural killer cells, viruses and cancer.

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

Natural-killer cells and dendritic cells: "l'union fait la force".

CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells

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21647-21652

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scholarly article

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10.1073/PNAS.1012128107

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50

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107

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2010-11-22T00:00:00Z

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49629438

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21098276

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3003106

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