Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.
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The binding sites for cocaine and dopamine in the dopamine transporter overlapBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersReceptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling.Discovery of novel selective serotonin reuptake inhibitors through development of a protein-based pharmacophore.Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transportersInteraction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptorsDopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter.Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidateHow dopamine transporter interacts with dopamine: insights from molecular modeling and simulation.A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants.A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.Mechanism for cocaine blocking the transport of dopamine: insights from molecular modeling and dynamics simulations(±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban).Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.The dopamine uptake inhibitor 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward.
P2860
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P2860
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@ast
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@en
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@nl
type
label
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@ast
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@en
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@nl
prefLabel
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@ast
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@en
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@nl
P2093
P356
P1476
Recognition of benztropine by ...... brane 1 aspartic acid residue.
@en
P2093
Alan P Kozikowski
Christopher K Surratt
Corry D Bondi
Okechukwu T Ukairo
Santosh S Kulkarni
Stephen Pan
P304
P356
10.1124/JPET.105.085829
P407
P577
2005-05-05T00:00:00Z