Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. - Wikidata - awgldk - TriplyDB

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

http://www.wikidata.org/entity/Q34421765

about

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity Mechanism of Anti-α-Synuclein Immunotherapy Disease-modifying therapeutic directions for Lewy-Body dementias Chaperones in Neurodegeneration Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Targeting heat shock proteins to modulate α-synuclein toxicity Molecular chaperones and co-chaperones in Parkinson disease Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.More than a Rumor Spreads in Parkinson's Disease Dysregulation of autophagy and mitochondrial function in Parkinson's disease Alpha-synuclein spreading in Parkinson's disease Assessment of α-synuclein secretion in mouse and human brain parenchyma Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss α-Synuclein oligomers impair neuronal microtubule-kinesin interplay.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.Development and screening of contrast agents for in vivo imaging of Parkinson's disease.Sequence-dependent internalization of aggregating peptides Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization The many faces of α-synuclein: from structure and toxicity to therapeutic target.Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins.Melittin restores proteasome function in an animal model of ALS Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.Hsc70 protein interaction with soluble and fibrillar alpha-synuclein Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Molecular chaperones in Parkinson's disease--present and future Icariin reduces α-synuclein over-expression by promoting α-synuclein degradation.Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.Trans-cellular propagation of Tau aggregation by fibrillar species Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

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P2860

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

http://www.wikidata.org/entity/Q34421765

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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Heat-shock protein 70 modulate ...... scues trans-synaptic toxicity.

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Charles Glabe

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Daniel Joyner

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Karin M Danzer

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Pamela J McLean

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Preeti Putcha

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Tadafumi Hashimoto

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Wolfgang P Ruf

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P2860

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

Staging of brain pathology related to sporadic Parkinson's disease

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

Formation of toxic oligomeric alpha-synuclein species in living cells

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways.

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10.1096/FJ.10-164624

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1

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25

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