Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.
about
Two dimensional blue native/SDS-PAGE to identify mitochondrial complex I subunits modified by 4-hydroxynonenal (HNE).Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation.Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's diseaseOCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseDocosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cellsDual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia.An ECSIT-centric view of Alzheimer's disease.Oxidative stress and lipid peroxidation are upstream of amyloid pathology.Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.The neuropathology of obesity: insights from human disease.From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease.Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway.Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.MEF2D Mediates the Neuroprotective Effect of Methylene Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells.Calsenilin contributes to neuronal cell death in ischemic stroke.Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal.Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease.Oxidant/Antioxidant Imbalance in Alzheimer's Disease: Therapeutic and Diagnostic Prospects.Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.Colocalization of Aluminum and Iron in Nuclei of Nerve Cells in Brains of Patients with Alzheimer's Disease
P2860
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P2860
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@ast
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@en
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@nl
type
label
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@ast
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@en
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@nl
prefLabel
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@ast
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@en
Oxidative lipid modification o ...... tivity in Alzheimer's disease.
@nl
P2093
P2860
P50
P1433
P1476
Oxidative lipid modification o ...... ctivity in Alzheimer's disease
@en
P2093
A-Ryeong Gwon
Aiwu Cheng
Charles E Dann
Dong-Hoon Hyun
Jong-Sung Park
Saerom Kim
Sang-Ha Baik
Seol-Hee Kim
Sic L Chan
Sunghee Yang
P2860
P304
P356
10.1111/J.1474-9726.2012.00817.X
P577
2012-04-09T00:00:00Z