Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy - Wikidata - awgldk - TriplyDB

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy

http://www.wikidata.org/entity/Q34442070

about

An experimental approach to study the function of mitochondria in cardiomyopathy The ubiquitin-proteasome system and cardiovascular disease Neuropathy- and myopathy-associated mutations in human small heat shock proteins: Characteristics and evolutionary history of the mutation sites Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil Heart mitochondrial proteome study elucidates changes in cardiac energy metabolism and antioxidant PRDX3 in human dilated cardiomyopathy Alpha B-crystallin suppresses pressure overload cardiac hypertrophy alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability.Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.Dystrophic Cardiomyopathy-Potential Role of Calcium in Pathogenesis, Treatment and Novel Therapies Radiation-induced alterations in mitochondria of the rat heart.BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity.Manipulation of death pathways in desmin-related cardiomyopathy Proteomic profiling of endothelin-1-stimulated hypertrophic cardiomyocytes reveals the increase of four different desmin species and alpha-B-crystallin.Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity.Protein quality control in protection against systolic overload cardiomyopathy: the long term role of small heat shock proteins Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells.Mutants of human αB-crystallin cause enhanced protein aggregation and apoptosis in mammalian cells: influence of co-expression of HspB1.Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes.Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.Desmin-related cardiomyopathy: an unfolding story ATP synthase subunit alpha and LV mass in ischaemic human hearts.Proteasome functional insufficiency in cardiac pathogenesis.Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy.Autophagy in cardiac plasticity and disease Systemic Inflammatory Response Syndrome After Contentious-Flow Left Ventricular Assist Device Implantation and Change in Platelet Mitochondrial Membrane Potential.Mutation of delta-sarcoglycan is associated with Ca(2+) -dependent vascular remodeling in the Syrian hamster.Novel roles for α-crystallins in retinal function and disease.Single-walled carbon nanotubes alter cytochrome c electron transfer and modulate mitochondrial function Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse.Autophagy is an adaptive response in desmin-related cardiomyopathy.Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction.

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Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Mitochondrial dysfunction and ...... desmin-related cardiomyopathy

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Alina Maloyan

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Atsushi Sanbe

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Dustin Robinson

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Elizabeth Murphy

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Hanna Osinska

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Jeffrey Robbins

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Ken-ichi Imahashi

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P2860

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes

Oxidative stress in neurodegeneration: cause or consequence?

Desmin myopathy.

A mechanistic role for cardiac myocyte apoptosis in heart failure.

Desmin cytoskeleton: a potential regulator of muscle mitochondrial behavior and function.

Mitochondrial control of neuron death and its role in neurodegenerative disorders.

Mechanisms of apoptosis in the heart.

Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols.

Desminopathies in muscle disease.

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