Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA. - Wikidata - awgldk - TriplyDB

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

http://www.wikidata.org/entity/Q34459792

about

Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.Akt2: a role in breast cancer metastasis Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme Drugging the cancer kinome: progress and challenges in developing personalized molecular cancer therapeutics Progress toward in vivo use of siRNAs-II Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.Ligand-free estrogen receptor activity complements IGF1R to induce the proliferation of the MCF-7 breast cancer cells.PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer.Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase Downregulation of PI3Kcb utilizing adenovirus-mediated transfer of siRNA attenuates bone cancer pain.Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948.The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck.Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins.Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice.Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.Potential applications of RNA interference technology in the treatment of cancer.Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase.Mitochondrial biogenesis in the axons of vertebrate peripheral neurons Phosphoinositide 3-kinases in cell migration.Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.Down-regulation of p110β expression increases chemosensitivity of colon cancer cell lines to oxaliplatin.Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells.ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells Down-regulation of Bcl-XL by RNA interference suppresses cell growth and induces apoptosis in human esophageal cancer cells.Survivin--an attractive target for RNAi in non-Hodgkin's lymphoma, Daudi cell line as a model.Inducible shRNA expression for application in a prostate cancer mouse model.Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.Downregulation of PIK3CB by siRNA suppresses malignant glioma cell growth in vitro and in vivo.A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway.Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs.TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2.

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Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

http://www.wikidata.org/entity/Q34459792

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Functional studies of the PI

@nl

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

@ast

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

@en

type

label

Functional studies of the PI

@nl

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

@ast

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

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prefLabel

Functional studies of the PI

@nl

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

@ast

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

@en

P1433

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P1433

Nucleic Acids Research

P1476

Functional studies of the PI(3 ...... synthetic and expressed siRNA.

@en

P2093

Anke Klippel

http://www.w3.org/2001/XMLSchema#string

Frank Czauderna

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Hüseyin Aygün

http://www.w3.org/2001/XMLSchema#string

Jörg Kaufmann

http://www.w3.org/2001/XMLSchema#string

Klaus Giese

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Melanie Fechtner

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Wolfgang Arnold

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P2860

Stable suppression of gene expression by RNAi in mammalian cells

Role of polyadenylation in nucleocytoplasmic transport of mRNA

RNA interference is mediated by 21- and 22-nucleotide RNAs

Role for a bidentate ribonuclease in the initiation step of RNA interference

A system for stable expression of short interfering RNAs in mammalian cells

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

P304

670-682

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scholarly article

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10.1093/NAR/GKG141

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2

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31

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2003-01-01T00:00:00Z

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274435092

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12527776

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140507

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