Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase - Wikidata - awgldk - TriplyDB

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

http://www.wikidata.org/entity/Q34335162

about

A beta version of life: p110β takes center stage p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors Should individual PI3 kinase isoforms be targeted in cancer?Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage The PI3K pathway as drug target in human cancer PI3K and AKT: Unfaithful Partners in Cancer Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells New molecular targets in mantle cell lymphoma Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies Molecular pathways: targeting phosphoinositide 3-kinase p110-delta in chronic lymphocytic leukemia Will kinase inhibitors make it as glioblastoma drugs?Phosphoinositides: tiny lipids with giant impact on cell regulation The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration A frequent kinase domain mutation that changes the interaction between PI3K and the membrane The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism Signaling by the phosphoinositide 3-kinase family in immune cells Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals.Phosphatidylinositol 3-kinase: the oncoprotein.A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation Novel PI3Kγ mutation in a 44-year-old man with chronic infections and chronic pelvic pain Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.Essential role of Stat3 in PI3K-induced oncogenic transformation A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma.

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P2860

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

http://www.wikidata.org/entity/Q34335162

description

2006 nî lūn-bûn

@nan

2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@ast

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@en

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@nl

type

label

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

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Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@en

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@nl

prefLabel

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@ast

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@en

Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@nl

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PNAS.0510772103

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Proceedings of the National Academy of Sciences of the United States of America

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Oncogenic transformation induc ...... ss I phosphoinositide 3-kinase

@en

P2093

Adam Denley

http://www.w3.org/2001/XMLSchema#string

Bart Vanhaesebroeck

http://www.w3.org/2001/XMLSchema#string

Sohye Kang

http://www.w3.org/2001/XMLSchema#string

P2860

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

P110delta, a novel phosphoinositide 3-kinase in leukocytes

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

High frequency of mutations of the PIK3CA gene in human cancers

Signaling by distinct classes of phosphoinositide 3-kinases

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1289-1294

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scholarly article

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5

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103

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