Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.
about
Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tailDNAM-1 and PVR regulate monocyte migration through endothelial junctionsActivation states of blood eosinophils in asthmaNeutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.Efalizumab binding to the LFA-1 L I domain blocks ICAM-1 binding via steric hindranceStructure of an integrin with an αI domain, complement receptor type 4Structure ofStreptococcus agalactiaetip pilin GBS104: a model for GBS pili assembly and host interactionsAssociation of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive stateChemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrestStructural basis of integrin regulation and signalingSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamAllosteric Regulation of E-Cadherin Adhesion.Alterations in immunodominance of Streptococcus mutans AgI/II: lessons learned from immunomodulatory antibodiesTwo stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region.Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophilsA small molecule agonist of an integrin, alphaLbeta2.Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.The N-terminal region and the mid-region complex of the integrin beta 2 subunit.Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.Force spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.αMβ₂ integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formationIntegrin structure: new twists and turns in dynamic cell adhesion.Mechanisms contributing to the activity of integrins on leukocytes.Genetic analysis of integrin activation in T lymphocytes.Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity stateAL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.Organization of the integrin LFA-1 in nanoclusters regulates its activity.Integrins, cations and ligands: making the connection.The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsRegulation of integrin affinity on cell surfacesReconstruction of integrin activation.Src family kinases mediate neutrophil adhesion to adherent platelets.Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
P2860
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P2860
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Locking in alternate conformat ...... nships among integrin domains.
@ast
Locking in alternate conformat ...... nships among integrin domains.
@en
Locking in alternate conformat ...... nships among integrin domains.
@nl
type
label
Locking in alternate conformat ...... nships among integrin domains.
@ast
Locking in alternate conformat ...... nships among integrin domains.
@en
Locking in alternate conformat ...... nships among integrin domains.
@nl
prefLabel
Locking in alternate conformat ...... nships among integrin domains.
@ast
Locking in alternate conformat ...... nships among integrin domains.
@en
Locking in alternate conformat ...... nships among integrin domains.
@nl
P2093
P2860
P356
P1476
Locking in alternate conformat ...... nships among integrin domains.
@en
P2093
P2860
P304
P356
10.1073/PNAS.041618598
P407
P577
2001-02-01T00:00:00Z