Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.
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Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulatorsDiscovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channelsAnalysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loopSpider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs.Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels.The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouriTargeting voltage sensors in sodium channels with spider toxins.Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.The activation effect of hainantoxin-I, a peptide toxin from the Chinese spider, Ornithoctonus hainana, on intermediate-conductance Ca2+-activated K+ channels.Molecular Cloning and Sequence Analysis of the cDNAs Encoding Toxin-Like Peptides from the Venom Glands of Tarantula Grammostola rosea.Voltage-gated sodium channel modulation by scorpion alpha-toxins.Spider peptide toxins as leads for drug development.Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and MygalomorphaeAn efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV.Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensorsAction potential initiation in neocortical inhibitory interneurons.Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.Palmitoylation influences the function and pharmacology of sodium channels.Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.Animal toxins can alter the function of Nav1.8 and Nav1.9.Peptidomic and transcriptomic profiling of four distinct spider venomsCharacterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp ScreeningTarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.Deconstructing voltage sensor function and pharmacology in sodium channels.Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.Proteome and peptidome profiling of spider venoms.Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis.Synthesis, solution structure, and phylum selectivity of a spider delta-toxin that slows inactivation of specific voltage-gated sodium channel subtypes.Subtype-selective targeting of voltage-gated sodium channels.Advances in targeting voltage-gated sodium channels with small molecules.Animal toxins influence voltage-gated sodium channel function.Venom-based biotoxins as potential analgesics.
P2860
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P2860
Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@ast
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@en
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@nl
type
label
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@ast
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@en
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@nl
prefLabel
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@ast
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@en
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@nl
P2093
P356
P1476
Four novel tarantula toxins as ...... gated sodium channel subtypes.
@en
P2093
Frank Bosmans
Jan Tytgat
Lachlan Rash
Pierre Escoubas
Shunyi Zhu
Sylvie Diochot
P304
P356
10.1124/MOL.105.015941
P577
2005-11-02T00:00:00Z