Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. - Wikidata - awgldk - TriplyDB

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

http://www.wikidata.org/entity/Q34473189

about

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species.Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.Modeling Huntington disease in yeast: perspectives and future directions.Growth Hormone Deteriorates the Functional Outcome in an Experimental Model of Huntington's Disease Induced by 3-Nitropionic Acid The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review).CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.Inhibitors of metabolism rescue cell death in Huntington's disease models.Human pluripotent stem cells: applications and challenges in neurological diseases.Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure.Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington's-Like Symptoms Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington's Disease.Transcriptional signatures in Huntington's disease.A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease.Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism.Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding.The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.

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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

http://www.wikidata.org/entity/Q34473189

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Mutant huntingtin alters MAPK ...... untingtin-associated toxicity.

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Human Molecular Genetics

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Mutant huntingtin alters MAPK ...... huntingtin-associated toxicity

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Aleksey Kazantsev

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Andrew Strand

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Barbara L Apostol

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Erik S Schweitzer

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J Lawrence Marsh

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James M Olson

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Judit Pallos

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Jun Wu

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Katalin Illes

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Leslie Michels Thompson

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273-285

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scholarly article

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10.1093/HMG/DDI443

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2

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15

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7440018

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16330479

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corpus striatum