Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. - Wikidata - awgldk - TriplyDB

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

http://www.wikidata.org/entity/Q34478968

about

Chemical genetics approaches for selective intervention in epigenetics Drugging the undruggables: exploring the ubiquitin system for drug development Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Targeting protein function: the expanding toolkit for conditional disruption Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.Drug Discovery Targeting Bromodomain-Containing Protein 4.Selective BET bromodomain inhibition as an antifungal therapeutic strategy Selective degradation of splicing factor CAPERα by anticancer sulfonamides.Induced protein degradation: an emerging drug discovery paradigm.Design and characterization of bivalent BET inhibitors.Structural basis of PROTAC cooperative recognition for selective protein degradation Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries.PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer.Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.Small molecules and their role in effective preclinical target validation.Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.Chemical Methods to Knock Down the Amyloid Proteins.BET Proteins: An Approach to Future Therapies in Transplantation.Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Targeted Protein Degradation by Small Molecules.Targeting Cancer Cells with BET Bromodomain Inhibitors.Waste disposal-An attractive strategy for cancer therapy.Targeted protein knockdown using small molecule degraders.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.An affinity-directed protein missile system for targeted proteolysis.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Targeting endogenous proteins for degradation through the affinity-directed protein missile system.BET inhibitors as novel therapeutic agents in breast cancer.KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival.Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

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P2860

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

http://www.wikidata.org/entity/Q34478968

description

2015 nî lūn-bûn

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2015 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2015 թվականի հունիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

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type

label

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

@en

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

@nl

prefLabel

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

@ast

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

@en

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

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ACSCHEMBIO.5B00216

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ACS Chemical Biology

P1476

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

@en

P2093

Alessio Ciulli

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Kwok-Ho Chan

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Michael Zengerle

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P2860

RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Selective inhibition of BET bromodomains

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Suppression of inflammation by a synthetic histone mimic

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor

Targeting bromodomains: epigenetic readers of lysine acetylation

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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1770-1777

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scholarly article

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10.1021/ACSCHEMBIO.5B00216

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8

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10

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2015-06-16T00:00:00Z

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277599379

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26035625

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4548256

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