Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.
about
Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugsPharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
P2860
Q45873447-C2A2A49C-1335-4D4E-93C8-EA1C921AFCA2Q47294366-E8DEF199-5C73-4FBB-89B0-11CBC3CBEF36Q47324161-C3002D27-E737-4FBF-866D-9E479BBF7257Q47423838-428F58E1-F524-41D5-A0CC-19D155C1DAC2Q52323183-AEE35F29-1716-4886-AE64-391780101E1AQ52653329-2F7A2B4A-DCFE-493C-801F-49C2A43926C6Q54992503-60DE9933-04D7-460F-A1E7-09344F2CDD3CQ58738119-AF8F3D6E-7B85-40C8-ACB2-20E8702E7FA3Q58756135-EE77A531-40AA-4B72-9AD9-A71BAE61C320
P2860
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
Impact of Target Warhead and L ...... T726) BET Inhibitor Scaffolds.
@en
type
label
Impact of Target Warhead and L ...... T726) BET Inhibitor Scaffolds.
@en
prefLabel
Impact of Target Warhead and L ...... T726) BET Inhibitor Scaffolds.
@en
P2093
P2860
P1476
Impact of Target Warhead and L ...... T726) BET Inhibitor Scaffolds.
@en
P2093
Andrea Testa
Kwok-Ho Chan
Michael Zengerle
P2860
P304
P356
10.1021/ACS.JMEDCHEM.6B01912
P407
P577
2017-06-08T00:00:00Z