Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
about
Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic DesignSyntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffoldStructural–Functional Studies of Burkholderia cenocepacia d -Glycero-β- d -manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence PropertiesSynthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC InhibitorsStructure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton TransferStructural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxCA Complete Pathway Model for Lipid A Biosynthesis in Escherichia coliThe UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane.Gonorrhea - an evolving disease of the new millennium.Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC InhibitorsDrug-target residence time: critical information for lead optimization.DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicusValidation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli.Translating slow-binding inhibition kinetics into cellular and in vivo effectsTransposon Mutagenesis Paired with Deep Sequencing of Caulobacter crescentus under Uranium Stress Reveals Genes Essential for Detoxification and Stress ToleranceToxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.Novel cationic peptide TP359 down-regulates the expression of outer membrane biogenesis genes in Pseudomonas aeruginosa: a potential TP359 anti-microbial mechanism.Enzyme Tunnels and Gates As Relevant Targets in Drug Design.Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation.Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosisMutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.Drug design from the cryptic inhibitor envelope.Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli.Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumanniiStructure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesisA new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466.Drug Target Identification and Elucidation of Natural Inhibitors for Bordetella petrii: An In Silico Study.Understanding efflux in Gram-negative bacteria: opportunities for drug discovery.Update on carbohydrate-containing antibacterial agents.New antibacterial agents: patent applications published in 2011.Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.Using bacterial genomes and essential genes for the development of new antibiotics.Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm.LpxC Inhibitors as Effective Therapy Against Multidrug Resistant Bacterial Infections.LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.
P2860
Q27666335-0C31DB94-D1BB-4063-AE42-CF5C52F8BDF3Q27666425-3CFF68F3-32D3-4685-B992-3F503883B2E1Q27675559-65CA977E-5CC2-43FB-BC9F-5F74F65DE19AQ27679369-FA992826-6853-4170-9488-39F553F0614CQ27680209-91CE0082-95DD-4318-A7E0-2AF9BB9E2E13Q27680233-694703A6-11D5-44AE-BBA4-1957CC5BCC71Q28546808-DBA21451-4EA5-4B68-90D4-8B57722E5152Q30090075-E89D2C99-EA3D-4811-B2F2-8A7E201B952FQ30152829-C0328074-069C-4567-BF9D-B9B1FE1472FDQ30235031-7F9ECB79-AEE0-4010-8BF8-E4572B7509D1Q30501560-D373E7E9-A6EF-41B2-A935-32E47028FE81Q33424246-846EC83F-4A71-487A-B196-C69614069118Q33754713-CBC841BD-1D58-4F88-9DD9-034C631283DDQ34054343-47BE1781-6434-40AC-80AD-61AC59C6D864Q34302323-FA19F003-2E91-4CCC-98B7-F0F49F0AA2ECQ34715492-EDAA6799-1851-48C8-AD90-EC1ACEEC4FB7Q35954896-5DF7A3AA-0E7E-427E-94E6-DDEF745591A7Q36028573-53AD6816-50DC-40C5-98BE-DB51C49C4F26Q36104259-A200CF53-95AA-4517-AF99-CC2660D807FAQ36109402-D453D72E-2BC4-4B0A-ACC4-015F83B72D4CQ36221405-A20BA4F3-5692-4EC6-AA08-3BE6DBD6E6E1Q36346024-44E13D48-FF9E-4C61-A851-F24847AA6923Q36457770-F23E9352-B40C-4EF2-A3B5-C1661F93C6E9Q36635902-2988D28D-4A97-4D1E-80F5-04D5326F4BA8Q36637019-566CB83E-BD5B-44A6-9636-116AF1630592Q36710583-E4238E5E-7A2D-4E13-91B3-B1A8D4EF07EBQ36781189-402A20BE-8F70-47E4-BB17-8339D86AFC7EQ37120148-42F80591-EDAD-4192-97D2-B578F6C28434Q37368288-44F02F4C-1F2B-4B2B-9DB9-9905DB0E8EB4Q37497388-B3ED713E-35B5-43AF-8D0D-774625738411Q37619000-4BE89C33-0274-4C68-866D-BA5E8A0D07A3Q38011247-6D97B675-8A95-43D5-884B-0B13990E9FD9Q38089193-84E178FA-7942-4AD7-BA12-FFCBF62A7AB2Q38172657-B70316C0-366E-416A-B4A3-138AA2495000Q38386624-42BAD39E-1A7F-4B3B-A5AE-7E81F588B4C2Q39035296-228F0E40-FAB1-4CF6-862C-87D8DDEAA8A8Q39096288-7969493C-64E9-4797-A751-D2F826430BA0Q40230660-BF6C517C-1FDE-4252-B328-AE17ACBE3EA7Q40890396-B9FEF3DA-E9BE-46E0-ABAF-E67AF1CE3C77Q41383264-B1314A15-CD9C-4BE9-8598-A1E03AEA808A
P2860
Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@ast
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@en
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@nl
type
label
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@ast
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@en
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@nl
prefLabel
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@ast
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@en
Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.
@nl
P2860
P1476
Mechanism and inhibition of Lp ...... of bacterial lipid A synthesis
@en
P2093
Adam W Barb
P2860
P356
10.2174/138920108783497668
P50
P577
2008-02-01T00:00:00Z