Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.
about
Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responsesFmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expressionMutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.Exploration of chlamydial type III secretion system reconstitution in Escherichia coli.Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.Using small molecules to dissect mechanisms of microbial pathogenesis.Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loopInhibition of matrix metalloproteinases protects mice from ascending infection and chronic disease manifestations resulting from urogenital Chlamydia muridarum infectionRegulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles.Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis.Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells.Productive Chlamydia trachomatis lymphogranuloma venereum 434 infection in cells with augmented or inactivated autophagic activitiesInhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitorReduced display of tumor necrosis factor receptor I at the host cell surface supports infection with Chlamydia trachomatis.Expression, purification, and activity assay of peptide deformylase from Escherichia coli and Staphylococcus aureus.Identification of a strong and specific antichlamydial N-acylhydrazone.A profiling platform for the identification of selective metalloprotease inhibitors.Resveratrol Inhibits Propagation of Chlamydia trachomatis in McCoy Cells.Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth.
P2860
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P2860
Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@ast
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@en
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@nl
type
label
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@ast
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@en
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@nl
altLabel
Metalloprotease Inhibitors GM6 ...... e Deformylase of the Bacterium
@en
prefLabel
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@ast
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@en
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@nl
P2093
P2860
P356
P1476
Metalloprotease inhibitors GM6 ...... deformylase of the bacterium.
@en
P2093
Amit Balakrishnan
Bhairavi Patel
Guangming Zhong
Huizhou Fan
Niseema Pachikara
Stephan A Sieber
P2860
P304
16691-16699
P356
10.1074/JBC.M513648200
P407
P577
2006-03-24T00:00:00Z