Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.
about
New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitorsNon-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis.Drug forecast - the peptide deformylase inhibitors as antibacterial agents.Double trouble: medical implications of genetic duplication and amplification in bacteria.Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis.Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.Pharmacokinetics and unexpected safety issues of LBM415, a novel oral peptide deformylase inhibitor.
P2860
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P2860
Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@ast
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@en
type
label
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@ast
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@en
prefLabel
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@ast
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@en
P2093
P2860
P356
P1476
Reduced susceptibility of Haem ...... omosomal def gene copy number.
@en
P2093
Brigitte Wiedmann
Charles R Dean
Daniel Wall
Denis M Daigle
Dieter Mueller
Hans Voshol
Heather Kamp
James Koehn
Jan van Oostrum
Jennifer A Leeds
P2860
P304
P356
10.1128/AAC.01103-06
P407
P577
2007-01-12T00:00:00Z