Using small molecules to dissect mechanisms of microbial pathogenesis.
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Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responsesRational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBBestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidasesInteraction of virstatin with human serum albumin: spectroscopic analysis and molecular modelingCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsA 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii.Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.Novel chiral skeletons for drug discovery: antibacterial tetramic acids.Evaluation of sulfatase-directed quinone methide traps for proteomics.Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.Target deconvolution techniques in modern phenotypic profiling.Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis.Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains.Far-red fluorogenic probes for esterase and lipase detection.Antibacterials from the sea.Activity-based probes: discovering new biology and new drug targets.A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA.Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.Novel drug discovery for Chagas disease.Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions.Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.Mining the Active Proteome of Arabidopsis thaliana.Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitorsAn expanded set of fluorogenic sulfatase activity probesChemical signaling in the gastrointestinal tract.The mechanism of caseinolytic protease (ClpP) inhibition.Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin.
P2860
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P2860
Using small molecules to dissect mechanisms of microbial pathogenesis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Using small molecules to dissect mechanisms of microbial pathogenesis.
@ast
Using small molecules to dissect mechanisms of microbial pathogenesis.
@en
type
label
Using small molecules to dissect mechanisms of microbial pathogenesis.
@ast
Using small molecules to dissect mechanisms of microbial pathogenesis.
@en
prefLabel
Using small molecules to dissect mechanisms of microbial pathogenesis.
@ast
Using small molecules to dissect mechanisms of microbial pathogenesis.
@en
P2860
P356
P1433
P1476
Using small molecules to dissect mechanisms of microbial pathogenesis.
@en
P2093
Aaron W Puri
P2860
P304
P356
10.1021/CB9001409
P577
2009-08-01T00:00:00Z