Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint
about
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombinationWhat goes on must come off: phosphatases gate-crash the DNA damage responsePP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponsePhysiological regulation of Akt activity and stability.The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.Phosphatases in the cellular response to DNA damage.Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiationThe role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitDbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extractsDirect Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasiaCell cycle regulation of DNA replication.Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1Control of DNA replication by the nucleus/cytoplasm ratio in Xenopus.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.Beyond ATM: the protein kinase landscape of the DNA damage response.Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage.Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.Aven-dependent activation of ATM following DNA damage.Polyomavirus small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression.HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.Investigating the role of Rts1 in DNA replication initiation.Cdc7 is an active kinase in human cancer cells undergoing replication stress.Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1
P2860
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P2860
Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint
description
2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@ast
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@en
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@nl
type
label
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@ast
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@en
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@nl
prefLabel
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@ast
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@en
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@nl
P2093
P2860
P1476
Protein phosphatase 2A antagon ...... ependent DNA damage checkpoint
@en
P2093
Danny M Chou
Gernot Walter
Johannes C Walter
Paris Petersen
Tony Hunter
Zhongsheng You
P2860
P304
P356
10.1128/MCB.26.5.1997-2011.2006
P407
P577
2006-03-01T00:00:00Z