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A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acidsNew Approaches to the Role of Thrombin in Acute Coronary Syndromes: Quo Vadis Bivalirudin, a Direct Thrombin Inhibitor?Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical SensingMechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217ACrystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4Structural identification of the pathway of long-range communication in an allosteric enzymeMolecular basis of thrombomodulin activation of slow thrombinRigidification of the autolysis loop enhances Na+ binding to thrombinInteraction of Thrombin with Sucrose OctasulfateProteolysis of human thrombin generates novel host defense peptides.The dynamic structure of thrombin in solutionHow Na+ activates thrombin--a review of the functional and structural data.New parenteral anticoagulants in development.Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism.Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.The extended cleavage specificity of human thrombin.Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.Sulodexide: a renewed interest in this glycosaminoglycan.Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.Origin of serpin-mediated regulation of coagulation and blood pressureAllostery in trypsin-like proteases suggests new therapeutic strategies.The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin.A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.Thrombosis: Novel nanomedical concepts of diagnosis and treatmentEmpirical and theoretical phenotypic discrimination.BSA Nanoparticles for siRNA Delivery: Coating Effects on Nanoparticle Properties, Plasma Protein Adsorption, and In Vitro siRNA DeliveryDesign and characterization of an APC-specific serpin for the treatment of hemophilia.Thrombin.Potential role of new anticoagulants for prevention and treatment of venous thromboembolism in cancer patients.Comparison of the clinical and morphologic characteristics of culprit lesions in unstable angina and non-ST-elevation myocardial infarction.Concerns regarding the use of dabigatran for stroke prevention in atrial fibrillation.Update on the physiology and pathology of factor IX activation by factor XIa.NMR reveals a dynamic allosteric pathway in thrombin.Which antithrombin for whom? Identifying the patient population that benefits most from novel antithrombin agents.Nanotheragnostic applications for ischemic and hemorrhagic strokes: improved delivery for a better prognosis.Using aptamers as capture reagents in bead-based assay systems for diagnostics and hit identification.Thrombin a-chain: activation remnant or allosteric effector?
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
An overview of the structure and function of thrombin.
@ast
An overview of the structure and function of thrombin.
@en
An overview of the structure and function of thrombin.
@nl
type
label
An overview of the structure and function of thrombin.
@ast
An overview of the structure and function of thrombin.
@en
An overview of the structure and function of thrombin.
@nl
prefLabel
An overview of the structure and function of thrombin.
@ast
An overview of the structure and function of thrombin.
@en
An overview of the structure and function of thrombin.
@nl
P356
P1476
An overview of the structure and function of thrombin.
@en
P2093
Earl W Davie
John D Kulman
P356
10.1055/S-2006-939550
P478
32 Suppl 1
P577
2006-04-01T00:00:00Z