Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175. - Wikidata - awgldk - TriplyDB

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

http://www.wikidata.org/entity/Q34531481

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Corticostriatal Dysfunction in Huntington's Disease: The Basics Elusive roles for reactive astrocytes in neurodegenerative diseases Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/1 mouse model of Huntington's disease A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.High frequency stimulation of the subthalamic nucleus leads to presynaptic GABA(B)-dependent depression of subthalamo-nigral afferents Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington's Disease Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.Studies on the Q175 Knock-in Model of Huntington's Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain.Quantification assays for total and polyglutamine-expanded huntingtin proteins.Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.Microglial Activation in the Pathogenesis of Huntington's Disease.Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors An independent study of the preclinical efficacy of C2-8 in the R6/2 transgenic mouse model of Huntington's disease Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep.Components of the endocannabinoid and dopamine systems are dysregulated in Huntington's disease: analysis of publicly available microarray datasets.Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model.Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.Use of a force-sensing automated open field apparatus in a longitudinal study of multiple behavioral deficits in CAG140 Huntington's disease model mice Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington's disease Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

http://www.wikidata.org/entity/Q34531481

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2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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JOURNAL.PONE.0049838

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Comprehensive behavioral and m ...... f Huntington's disease: zQ175.

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Afshin Ghavami

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Andrea E Kudwa

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Carol Murphy

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Dani Brunner

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David Connor

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Jon Fitzpatrick

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Jose Beltran

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Judy Watson-Johnson

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Kristi McConnell

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P2860

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

Neurological abnormalities in a knock-in mouse model of Huntington's disease

Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease

Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

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scholarly article

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10.1371/JOURNAL.PONE.0049838

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12

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2012-12-20T00:00:00Z

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234040858

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23284626

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Huntington disease

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3527464

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