DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. - Wikidata - awgldk - TriplyDB

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

http://www.wikidata.org/entity/Q34595025

about

Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation Temporal regulation of Ig gene diversification revealed by single-cell imaging.Effects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.The evolution of transcription-associated biases of mutations across vertebrates Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.AID and somatic hypermutation.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation Controlling somatic hypermutation in immunoglobulin variable and switch regions.Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Mechanism and regulation of class switch recombination Class-switched memory B cells remodel BCRs within secondary germinal centers.Mismatch-mediated error prone repair at the immunoglobulin genes.Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.129-Derived Mouse Strains Express an Unstable but Catalytically Active DNA Polymerase Iota Variant Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stability UNG shapes the specificity of AID-induced somatic hypermutation.Does DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.Proteasomal degradation restricts the nuclear lifespan of AID Y-family DNA polymerases and their role in tolerance of cellular DNA damage.Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

P2860

Q27000758-957AD806-7F28-4DBA-83E4-73739CF80082 Q27324793-858E6C37-A92C-410D-8909-2D0F7A495ADC Q27677864-D7A295C3-B876-4718-A9CB-DC1FF6ADCC21 Q27937434-0DEC2AEB-26FA-46F4-B803-540824D864AD Q28241953-ECF5E6A4-7D65-4F20-A6D4-C79C7E24F897 Q30436370-89E067A6-06D6-4890-A339-B8EDBE1647B7 Q30566367-9A04BE37-8ABE-41FF-8052-AA279A517DEC Q33346216-B3477E39-9DFD-4476-A51A-A1FE2DE868E0 Q33557562-DB94D391-39B2-498A-86FA-E915E03CE050 Q33611202-B8F09C21-C97A-449B-8154-B2714687624D Q33743606-D12B3DEF-FE10-4056-B3E4-D012F42B1971 Q34118000-EF579F28-9785-420A-8BA4-52CAD6645777 Q34154230-11A580A8-DC7B-49D9-8DC5-0C90A1427625 Q34189624-082F0E30-144B-4BA1-8837-03765B45D136 Q34222332-6209E343-747F-437B-AE68-95DEE3473646 Q34401362-7D2D8AE2-58CD-45D0-9966-998570A0AFB4 Q34572374-6B77FB57-D011-4398-94F1-F9FAF254BCED Q34735827-C212910D-48C5-43CD-8C0A-A33FCAEF95D5 Q34764888-FF555A36-94E3-4B08-B2AC-345B2817165B Q35097102-ABA6596B-86CD-47DC-8866-686E649A6177 Q35605313-008CCBDD-77D9-42E8-98D6-E2EF0890A0A2 Q35783039-429CAB90-6F8A-4796-8911-CE4D945459B9 Q35884176-4DA24DB2-BEA9-4D68-86AE-A5DB9C58A1D5 Q35917435-E15CEF24-DEF1-4810-80B4-CA08E49888BB Q35946097-AB8435A5-5E60-45BA-8588-49269F08E9DE Q35989743-0CDC767F-9565-458C-954D-CE3488145234 Q36035857-2AD150B7-E19E-423A-B939-2C406CB34722 Q36118300-9F294217-B5EE-4056-9ED6-86EC164C18C8 Q36173864-50BA7827-939E-4447-9CCA-0C5C6A71BF3C Q36173942-A232195D-2CD2-463C-9FEC-2CC7AA7C6862 Q36229513-5900A6D9-DF25-4EB8-BF75-256D80F87F8D Q36376956-0E05FE75-D9A3-485D-972D-C40D6D7B861F Q36540495-3F8A5D58-EA73-4732-8FF0-EFDB1BFF7CD3 Q36684782-210066F0-EF28-431A-AB31-40EEDCA52972 Q36693193-BE92096E-3041-4F04-ABC7-12B09739DAB0 Q36699771-1115B88C-D430-473E-9D2E-E668055CA883 Q36778894-C76B85BF-F443-40C3-BBFB-93DB55449A3E Q36842394-F2EFA283-8D36-4CAA-B3AB-7AC9D0E5CDB2 Q36923850-9A60DB23-ADF7-4EDB-8D68-20CDFA37DEA4 Q36945144-E6C0CCB4-E8A6-48CD-97D2-9E716C7D5747

P2860

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

http://www.wikidata.org/entity/Q34595025

description

2006 nî lūn-bûn

@nan

2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@ast

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@en

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@nl

type

label

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@ast

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@en

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@nl

prefLabel

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@ast

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@en

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@nl

P1433

Q34595025-711DB003-E74B-4D65-869D-A84A24B098DF

P1476

Q34595025-0498590C-9C55-4834-BC14-4B9A18B324D8

P2093

Q34595025-3C9F5D09-28E5-466D-8387-E19FC0DA9778

Q34595025-3FC9A6B9-525C-412B-AF62-A1B2E1B4F401

Q34595025-4785A8F4-A118-4F7E-92F4-9924C1602B4C

Q34595025-966CE95A-7C5A-4F20-A426-D7B308511BCB

Q34595025-9FA375E4-6175-4806-B931-4CA55D549FF1

P2860

Q34595025-04D5C272-8D46-4E78-B73A-D58E10D1F70F

Q34595025-057F835C-F39B-40D5-8A29-C897F242332B

Q34595025-10E3A24F-7D1D-4AAE-A91C-AF4FC155990E

Q34595025-165A11FC-750A-4C14-A3BF-B3767797B85A

Q34595025-1BE07683-F96B-47F7-B7EC-1F9EF30DD19A

Q34595025-1E5B3336-EBA0-404D-AA41-6B7A585D47FE

Q34595025-2024F256-65D9-4B25-8FD5-0DB5063B3DB6

Q34595025-28A437C7-C7A0-44C1-B5E3-413A2615E270

Q34595025-2D3E4245-057F-4511-BB93-100BD1F8F4FC

Q34595025-3A136DB5-9E41-40AA-8945-B3ED0F9858AE

P304

Q34595025-AEDCE420-415B-4726-9930-9490AA2B46E7

P31

Q34595025-AAA53356-2F30-430B-B69B-1972E919E319

P356

Q34595025-E12CF2E0-8776-4167-9C0A-31DAEAA6019D

P407

Q34595025-9A0E37C8-B5E9-44A3-9B36-C015C64D89FA

P433

Q34595025-3081F26D-1C1F-43BA-B6FE-38A57FFD369C

P478

Q34595025-A4339991-1AB7-46B4-8571-0E3C52A0A9EE

P577

Q34595025-EDD1E4FE-26DE-4A99-8F13-54259048689D

P5875

Q34595025-F830759D-065C-46AE-83F2-4F2CA2388E4F

P698

Q34595025-DEFB06D4-4294-415B-B327-B7A9A27B71E3

P932

Q34595025-D5D769A3-F126-4729-8012-944D01865A0F

P356

P1433

Journal of Experimental Medicine

P1476

DNA polymerase eta is the sole ...... ne hypermutation in the mouse.

@en

P2093

Ahmad Faili

http://www.w3.org/2001/XMLSchema#string

Claude-Agnès Reynaud

http://www.w3.org/2001/XMLSchema#string

Frédéric Delbos

http://www.w3.org/2001/XMLSchema#string

Jean-Claude Weill

http://www.w3.org/2001/XMLSchema#string

Said Aoufouchi

http://www.w3.org/2001/XMLSchema#string

P2860

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Error rate and specificity of human and murine DNA polymerase eta

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

P304

17-23

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.20062131

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

204

http://www.w3.org/2001/XMLSchema#string

P577

2006-12-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6609423

http://www.w3.org/2001/XMLSchema#string

P698

17190840

http://www.w3.org/2001/XMLSchema#string

P932

2118439

http://www.w3.org/2001/XMLSchema#string