Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model.

Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model.

Item

http://www.wikidata.org/entity/Q34552084

Q34552084

about

Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities.Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1.Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches.First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences.Regioselective glucuronidation of flavonols by six human UGT1A isoforms.Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis.A new strategy to rapidly evaluate kinetics of glucuronide efflux by breast cancer resistance protein (BCRP/ABCG2).Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides.Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes.Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights.Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure-activity/property relationship-based approach in the study of bioavailability and bioactivity.Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids.3D-QSAR studies on UDP-glucuronosyltransferase 2B7 substrates using the pharmacophore and VolSurf approaches.

P2860

Q33567176-BF8BF329-E78D-4223-97F3-BDA2E504271D Q33649076-E9E44162-49F8-460F-B1DF-03E5CBEB9AAF Q36115752-01B7EC9D-BB30-4839-A812-DC9DB001B199 Q36132276-AC00287B-C09E-4EA3-9ADD-56A43B2239CF Q36132293-A897DD59-4D19-4F72-A2E3-17130C12CB43 Q36132317-87001C33-B3E5-47A6-A0A1-C302C5732CAB Q36185254-A735DF8F-59A1-4906-8F6B-F2CC47C28B2F Q36185275-219F304E-E21F-48ED-A8B7-CA568FFA0C11 Q37636069-E34FD99F-CBCC-4925-909B-B90CE544C898 Q37636079-7974097C-AD96-495B-A427-BC4F20C5E290 Q37710997-ACA649BF-2A24-4778-B041-C9925AD25467 Q37990054-24080E18-7F0E-414D-946B-207CC12E51B4 Q38086603-D8128C73-9E23-455A-94C4-59206FBE61DF Q38336527-E2B02F65-7621-43BF-81AA-CF549FFA169F Q38797489-3C2ED5D3-308B-4505-A04D-96F2E15A408F Q42228296-46BD0E73-2143-41F0-AA45-23313D2117FC Q51383600-428348BB-0505-4D0E-A180-2101F9134E7C

P2860

Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model.

Item

http://www.wikidata.org/entity/Q34552084

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu