Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells.
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Gene therapy for hemophiliaTolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicityStrategies to modulate immune responses: a new frontier for gene therapyHepatic gene transfer as a means of tolerance induction to transgene productsBALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: implications for cutaneous gene therapy.AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cellsDevelopment of Gene Transfer for Induction of Antigen-specific Tolerance.Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4.Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression.Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivoModulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver.Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in mice.Gene therapy for treatment of inherited haematological disorders.Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporineNonviral-mediated hepatic expression of IGF-I increases Treg levels and suppresses autoimmune diabetes in mice.Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.Genetically reprogrammed, liver-derived insulin-producing cells are glucose-responsive, but susceptible to autoimmune destruction in settings of murine model of type 1 diabetes.Gene therapy, bioengineered clotting factors and novel technologies for hemophilia treatment.Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.Capsid antibodies to different adeno-associated virus serotypes bind common regions.Inhibitor development.Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant miceEffective gene therapy for haemophilic mice with pathogenic factor IX antibodies.Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells.Role of regulatory T cells in tolerance to coagulation factors.AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.The complex and evolving story of T cell activation to AAV vector-encoded transgene products.AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?Immune tolerance induction in haemophilia: evidence and the way forward.Innate Immune Responses to AAV VectorsPre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors.Co-delivery of indoleamine 2,3-dioxygenase prevents loss of expression of an antigenic transgene in dystrophic mouse muscles.Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.Complexity of immune responses to AAV transgene products - Example of factor IX.Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia.Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-therapy-treated hemophilia A mice.Alternative Start Sites Downstream of Non-Sense Mutations Drive Antigen Presentation and Tolerance Induction to C-Terminal Epitopes.Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer.Measuring immune responses to recombinant AAV gene transfer.
P2860
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P2860
Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells.
description
2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@ast
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@en
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@nl
type
label
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@ast
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@en
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@nl
prefLabel
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@ast
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@en
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@nl
P2093
P2860
P356
P1476
Prevention of cytotoxic T lymp ...... er-induced regulatory T cells.
@en
P2093
Eric Dobrzynski
Federico Mingozzi
Lixin Wang
Roland W Herzog
P2860
P304
P356
10.1073/PNAS.0508685103
P407
P577
2006-03-10T00:00:00Z