Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
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Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia BGene therapy for hemophiliaAAV's anatomy: roadmap for optimizing vectors for translational successRole of cyclic AMP-dependent kinase response element-binding protein in recombinant adeno-associated virus-mediated transduction of heart muscle cells.Anti-inflammatory loaded poly-lactic glycolic acid nanoparticle formulations to enhance myocardial gene transfer: an in-vitro assessment of a drug/gene combination therapeutic approach for direct injection.Safety of AAV factor IX peripheral transvenular gene delivery to muscle in hemophilia B dogs.Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+ T cellsTransduction of skeletal muscles with common reporter genes can promote muscle fiber degeneration and inflammationPrevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells.A dystrophic muscle broadens the contribution and activation of immune cells reacting to rAAV gene transfer.Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer.Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene TransferMuscle-directed anti-Aβ single-chain antibody delivery via AAV1 reduces cerebral Aβ load in an Alzheimer's disease mouse model.Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector.Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.The complex and evolving story of T cell activation to AAV vector-encoded transgene products.Innate Immune Responses to AAV VectorsImmune Responses to AAV-Vectors, the Glybera Example from Bench to Bedside.Recent advances in gene therapy for lysosomal storage disorders.Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease.Complexity of immune responses to AAV transgene products - Example of factor IX.Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle.Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer.Muscle Gene Therapy for Hemophilia.Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer.Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transferImpact of preexisting vector immunity on the efficacy of adeno-associated virus-based HIV-1 Gag vaccines.Vaccines based on novel adeno-associated virus vectors elicit aberrant CD8+ T-cell responses in mice.Immune deviation by mucosal antigen administration suppresses gene-transfer-induced inhibitor formation to factor IX.Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy.TLR3 signaling does not affect organ-specific immune responses to factor IX in AAV gene therapy.A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque.Direct comparison of four adeno-associated virus serotypes in mediating the production of antiangiogenic proteins in mouse muscle.Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.Mir-142-3p target sequences reduce transgene-directed immunogenicity following intramuscular adeno-associated virus 1 vector-mediated gene delivery.Soluble TNF-α receptor secretion from healthy or dystrophic mice after AAV6-mediated muscle gene transfer.Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts.Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules.Major role of local immune responses in antibody formation to factor IX in AAV gene transfer.
P2860
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P2860
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@ast
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@en
type
label
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@ast
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@en
prefLabel
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@ast
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@en
P2093
P2860
P1433
P1476
Systemic protein delivery by muscle-gene transfer is limited by a local immune response.
@en
P2093
Alexander Schlachterman
Eric Dobrzynski
Lixin Wang
Roland W Herzog
P2860
P304
P356
10.1182/BLOOD-2004-03-0848
P407
P577
2005-02-15T00:00:00Z