The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.
about
The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stabilityStxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradationThe Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase ItchStructures of YAP protein domains reveal promising targets for development of new cancer drugsThe neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAPNew insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeuticsEmerging role of Hippo pathway in gastric and other gastrointestinal cancersStructure and apoptotic function of p73The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injuryp73 as a pharmaceutical target for cancer therapyMutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Isolation of putative FOXO1 genomic elements using an improved in vitro technique to isolate genomic regulatory sequencesThe antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.YAP accelerates Aβ(25-35)-induced apoptosis through upregulation of Bax expression by interaction with p73.Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neuronsThe Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets.When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.c-Abl phosphorylation of ΔNp63α is critical for cell viabilityNovel combination of sorafenib and celecoxib provides synergistic anti-proliferative and pro-apoptotic effects in human liver cancer cells.YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease.α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73.A functional variant rs1820453 in YAP1 and breast cancer risk in Chinese populationCharacterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling deviceRegulation of p73 activity by post-translational modifications.Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration.The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domainDNA damage response in cisplatin-induced nephrotoxicity.Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm.PML Surfs into HIPPO Tumor Suppressor Pathway.Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation.Therapeutic prospects for p73 and p63: rising from the shadow of p53.Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation.The p53 family and programmed cell deathLipopolysaccharide Induces Human Pulmonary Micro-Vascular Endothelial Apoptosis via the YAP Signaling Pathway.Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.p53-family proteins and their regulators: hubs and spokes in tumor suppression.
P2860
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P2860
The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@ast
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@en
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@nl
type
label
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@ast
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@en
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@nl
prefLabel
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@ast
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@en
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@nl
P2093
P2860
P356
P1476
The Yes-associated protein 1 s ...... ediated ubiquitination of p73.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.CDD.4402063
P50
P577
2006-11-17T00:00:00Z