Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. - Wikidata - awgldk - TriplyDB

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.

http://www.wikidata.org/entity/Q34946954

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Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro Drugging topoisomerases: lessons and challenges Advances in using PARP inhibitors to treat cancer Immunodetection of human topoisomerase I-DNA covalent complexes Genome-wide transcriptional effects of the anti-cancer agent camptothecin Phase II study of irinotecan in combination with temozolomide (TEMIRI) in children with recurrent or refractory medulloblastoma: a joint ITCC and SIOPE brain tumor study Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.Drugging the Cancers Addicted to DNA Repair.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitors Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Protein expression of DNA damage repair proteins dictates response to topoisomerase and PARP inhibitors in triple-negative breast cancer.Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage Removal of reactive oxygen species-induced 3'-blocked ends by XPF-ERCC1.Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex.Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay Isolation and quantitation of topoisomerase complexes accumulated on Escherichia coli chromosomal DNA.Lasonolide A, a potent and reversible inducer of chromosome condensation.DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.SbcCD-mediated processing of covalent gyrase-DNA complex in Escherichia coli.Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion

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Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.

http://www.wikidata.org/entity/Q34946954

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2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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Poly(ADP-ribose) polymerase an ...... DNA damage in mammalian cells.

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Poly(ADP-ribose) polymerase an ...... DNA damage in mammalian cells.

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P2093

James H Doroshow

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Jennifer A Seiler

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Keli K Agama

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Marie Regairaz

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Yong-Wei Zhang

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P2860

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Cellular roles of dna topoisomerases: a molecular perspective

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

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3607-3620

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10.1093/NAR/GKQ1304

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9

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39

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49748625

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21227924

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3089458

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