Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
about
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationImmunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophilsAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesFollicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesisLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsMutations, kataegis and translocations in B cells: understanding AID promiscuous activityPlasmacytoid dendritic cells of the gut: relevance to immunity and pathologyActivation of B cells by non-canonical helper signalsIgH chain class switch recombination: mechanism and regulationIntestinal IgA production and its role in host-microbe interactionDeconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and ImmunityRegulation of frontline antibody responses by innate immune signals.AID/APOBEC deaminases and cancerAID targeting: old mysteries and new challengesThe splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNAM17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in miceDouble strand break repair functions of histone H2AXThe AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutationInduction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.AUF1 is involved in splenic follicular B cell maintenanceIL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switchingAlternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVIDGeneration and repair of AID-initiated DNA lesions in B lymphocytes.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytesGenomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.Influence of switch region length on immunoglobulin class switch recombination.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and developmentDissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationCell intrinsic alterations underlie hematopoietic stem cell aging.Immunoglobulin responses at the mucosal interface.Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.
P2860
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P2860
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@ast
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@en
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@nl
type
label
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@ast
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@en
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@nl
prefLabel
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@ast
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@en
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@nl
P3181
P356
P1476
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
@en
P2093
Frederick W Alt
Jayanta Chaudhuri
P304
P3181
P356
10.1038/NRI1395
P407
P577
2004-07-01T00:00:00Z