A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. - Wikidata - awgldk - TriplyDB

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations.

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations.

http://www.wikidata.org/entity/Q34628968

about

Keeping mtDNA in shape between generations From bioblasts to mitochondria: ever expanding roles of mitochondria in cell physiology Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children Mitochondrial cytochrome c oxidase deficiency Mitochondrial DNA variation in human radiation and disease Organellar RNA editing Metabolic determinants of embryonic development and stem cell fate Regulation of entry into gametogenesis Evolution of the couple cytochrome c and cytochrome c oxidase in primates Mitochondrial genome changes and neurodegenerative diseases Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing Selection against heteroplasmy explains the evolution of uniparental inheritance of mitochondria Exclusion of dysfunctional mitochondria from Balbiani body during early oogenesis of Thermobia Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis Mitochondrial DNA disease and developmental implications for reproductive strategies Mitochondria: in sickness and in health Mitochondrial fission, fusion, and stress Mitochondria and cancer Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model Mitochondrial DNA mutations affect calcium handling in differentiated neurons.Female and male gamete mitochondria are distinct and complementary in transcription, structure, and genome function Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases.Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder Sequencing strategy for the whole mitochondrial genome resulting in high quality sequences.VisHiC--hierarchical functional enrichment analysis of microarray data Mitochondria, bioenergetics, and the epigenome in eukaryotic and human evolution New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.Fluorescent duplex allele-specific PCR and amplicon melting for rapid homogeneous mtDNA haplogroup H screening and sensitive mixture detection.Colloquium paper: bioenergetics, the origins of complexity, and the ascent of man.A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations.Transmission of mitochondrial DNA diseases and ways to prevent them.Mitochondrial DNA variant discovery and evaluation in human Cardiomyopathies through next-generation sequencing.Disease-associated mitochondrial mutations and the evolution of primate mitogenomes.Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.Does mtDNA nucleoid organization impact aging?Mitogenomes of polar bodies and corresponding oocytes.The role of mitochondrial DNA copy number in mammalian fertility.

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A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations.

http://www.wikidata.org/entity/Q34628968

description

2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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type

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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A mouse model of mitochondrial ...... gainst severe mtDNA mutations.

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Christophe Rocher

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Douglas C Wallace

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Grant R Macgregor

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Katrina G Waymire

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Mani A Vannan

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Navneet Narula

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Peng Li

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Pinar E Coskun

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Weiwei Fan

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P2860

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme.

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

Transfer of chloramphenicol-resistant mitochondrial DNA into the chimeric mouse

Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice.

The epidemiology of mitochondrial disorders--past, present and future.

Apoptosis in the ovary: molecular mechanisms.

Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine.

Effects of purifying and adaptive selection on regional variation in human mtDNA.

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.

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958-962

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