The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
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Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrationsAssociation of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC StudyEffects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretionGlucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention studyPhysiologic characterization of type 2 diabetes-related lociInteraction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescentsCommon missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrationsGenetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes careNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskAnalysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology studyThe PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulationGenome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traitsA bivariate genome-wide approach to metabolic syndrome: STAMPEED consortiumGenetic variation in GIPR influences the glucose and insulin responses to an oral glucose challengeNovel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traitsDisparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites.Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control studyMultiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.Genetics of type 2 diabetes in European populations.Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetesThe association between Mediterranean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: an analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk studyParadoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathwaysIdentification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese populationGenetic determinants of plasma triglyceridesGCKR variants increase triglycerides while protecting from insulin resistance in Chinese childrenLoci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health StudyThe common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.The heritability of beta cell function parameters in a mixed meal test design.Large scale meta-analyses of fasting plasma glucose raising variants in GCK, GCKR, MTNR1B and G6PC2 and their impacts on type 2 diabetes mellitus risk.Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphismGlucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.
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The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
description
2007 nî lūn-bûn
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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@ast
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@en
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@nl
type
label
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@ast
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@en
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@nl
prefLabel
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@ast
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@en
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@nl
P2093
P50
P1433
P1476
The GCKR rs780094 polymorphism ...... duced risk of type 2 diabetes.
@en
P2093
Albrechtsen A
Andersen G
Borch-Johnsen K
Burgdorf KS
Lauritzen T
Nielsen AL
Pedersen O
Rasmussen SS
P2888
P356
10.1007/S00125-007-0865-Z
P577
2007-11-16T00:00:00Z
P5875
P6179
1011149648