Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD - Wikidata - awgldk - TriplyDB

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

http://www.wikidata.org/entity/Q34655897

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Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier Animal models of age related macular degeneration RPE necroptosis in response to oxidative stress and in AMD Ironing out Ferroportin Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration Brain and retinal ferroportin 1 dysregulation in polycythaemia mice Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI.Animals as models of age-related macular degeneration: an imperfect measure of the truth.Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).Aceruloplasminemia: retinal histopathologic manifestations and iron-mediated melanosome degradation The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration Iron, the retina and the lens: a focused review.Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium.Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome Age-dependent and gender-specific changes in mouse tissue iron by strain.Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress.Mice with hepcidin-resistant ferroportin accumulate iron in the retina.Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.Iron-mediated retinal degeneration in haemojuvelin-knockout mice.Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger Iron metabolism in the eye: a review.The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli.Expression and function of iron-regulatory proteins in retina.Ocular changes in TgF344-AD rat model of Alzheimer's disease.Essential but toxic: controlling the flux of iron in the body.The regulation of iron transport.Role of iron in ischemia-induced neurodegeneration: mechanisms and insights.Retinal abnormalities in β-thalassemia major.Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis.

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

http://www.wikidata.org/entity/Q34655897

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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type

label

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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prefLabel

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

@ast

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

@en

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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Investigative Ophthalmology & Visual Science

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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Domenico Pratico

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John Beard

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Joshua L Dunaief

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Majda Hadziahmetovic

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Nadine Haddad

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Rong Wen

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Tzvete Dentchev

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Xining He

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Ying Song

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Z Leah Harris

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P2860

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

Drusen complement components C3a and C5a promote choroidal neovascularization

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Complement factor H polymorphism in age-related macular degeneration

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration

New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

Complement factor H polymorphism and age-related macular degeneration

Balancing acts: molecular control of mammalian iron metabolism

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2728-2736

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10.1167/IOVS.07-1472

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6

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49

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John D. Lambris

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5524935

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18326691

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2569891

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