NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. - Wikidata - awgldk - TriplyDB

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

http://www.wikidata.org/entity/Q34655913

about

Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae.Undercover: gene control by metabolites and metabolic enzymes Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2 Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.Intrinsically disordered proteins as molecular shields Axon degeneration: Molecular mechanisms of a self-destruction pathway Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity.Molecular basis for insecticide-enhanced thermotolerance in the brown planthopper Nilaparvata lugens Stål (Hemiptera:Delphacidae).A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.Wallerian degeneration, wld(s), and nmnat.Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo.An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations.NMNAT: It's an NAD+ synthase… It's a chaperone… It's a neuroprotector.Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway.Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Drosophila models reveal novel insights into mechanisms underlying neurodegeneration.Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons.Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress.Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

http://www.wikidata.org/entity/Q34655913

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@ast

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@en

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@nl

type

label

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@ast

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@en

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@nl

prefLabel

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@ast

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

@en

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

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P2093

Claire M Haueter

http://www.w3.org/2001/XMLSchema#string

Fan Zhang

http://www.w3.org/2001/XMLSchema#string

P Robin Hiesinger

http://www.w3.org/2001/XMLSchema#string

R Grace Zhai

http://www.w3.org/2001/XMLSchema#string

Yu Cao

http://www.w3.org/2001/XMLSchema#string

P2860

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

A local mechanism mediates NAD-dependent protection of axon degeneration

Structure of the universal stress protein of Haemophilus influenzae

Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis

Two distinct mechanisms operate in the reactivation of heat-denatured proteins by the mitochondrial Hsp70/Mdj1p/Yge1p chaperone system.

Protein disaggregation mediated by heat-shock protein Hsp104.

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins

Hsp90 as a capacitor for morphological evolution

Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation

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7189

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452

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1010479377

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18344983

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molecular chaperones

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3150538

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