CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
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The endocannabinoid system in normal and pathological brain ageingThe Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat proteinThe organic anion transporter (OAT) family: a systems biology perspectiveTwo for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivoAxonal transport plays a crucial role in mediating the axon-protective effects of NmNATNicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo.Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammalsNMNAT: It's an NAD+ synthase… It's a chaperone… It's a neuroprotector.An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.Impact of Genetic Reduction of NMNAT2 on Chemotherapy-Induced Losses in Cell Viability In Vitro and Peripheral Neuropathy In VivoNMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons.Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.NMNATs, evolutionarily conserved neuronal maintenance factors.Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model.Diversification of NAD biological role: the importance of location.Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.Wallerian degeneration: an emerging axon death pathway linking injury and disease.The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream targetDrug target identification at the crossroad of neuronal apoptosis and survival.Designer protein disaggregases to counter neurodegenerative disease.Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins.The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe AxonopathyThe role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration.A novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia.NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer's Disease Model.Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease.Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): consequences for mouse bladder development and function.The Influence of Nicotinamide on Health and Disease in the Central Nervous System.Presymptomatic change in microRNAs modulates Tau pathology.
P2860
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P2860
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@ast
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@en
type
label
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@ast
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@en
prefLabel
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@ast
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@en
P2093
P2860
P356
P1476
CREB-activity and nmnat2 trans ...... mouse model of human tauopathy
@en
P2093
Hui-Chen Lu
Kazuhiro Oka
M Cecilia Ljungberg
R Grace Zhai
Yousuf O Ali
P2860
P304
P356
10.1093/HMG/DDR492
P50
P577
2011-10-25T00:00:00Z