Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. - Wikidata - awgldk - TriplyDB

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.

http://www.wikidata.org/entity/Q34657500

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In-situ tumor vaccination: Bringing the fight to the tumor IDO2 in Immunomodulation and Autoimmune Disease IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.Vaccine prevention of cancer: can endogenous antigens be targeted?Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.Towards a genetic definition of cancer-associated inflammation: role of the IDO pathway Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.EMT and inflammation: inseparable actors of cancer progression.B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase IDO is a nodal pathogenic driver of lung cancer and metastasis development.IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer Immune suppression and immune activation in depression IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells.Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression.Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers.Classification of current anticancer immunotherapies HIV and the gut microbiota, partners in crime: breaking the vicious cycle to unearth new therapeutic targets.Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases.Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma.Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival.A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma.The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy.Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells.The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).

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P2860

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.

http://www.wikidata.org/entity/Q34657500

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Proceedings of the National Academy of Sciences of the United States of America

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Chronic inflammation that faci ...... ng indoleamine 2,3 dioxygenase

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Alejandro Peralta Soler

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Andrew L Mellor

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Burles A Johnson

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David J Kahler

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George C Prendergast

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James B Duhadaway

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Jeanene Pihkala

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Madhav D Sharma

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Mary E Everhart

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Phillip R Chandler

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P2860

Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

Inflammation and cancer

Tolerance, DCs and tryptophan: much ado about IDO

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

IDO expression by dendritic cells: tolerance and tryptophan catabolism

The immunobiology of cancer immunosurveillance and immunoediting

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

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105

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Alexander J Muller

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