mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.
about
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthMolecular therapy of colorectal cancer: progress and future directionsTurning off AKT: PHLPP as a drug targetLarge FK506-Binding Proteins Shape the Pharmacology of RapamycinMaximising the potential of AKT inhibitors as anti-cancer treatmentsSuppression of survival signalling pathways by the phosphatase PHLPPDifferential network analysis from cross-platform gene expression data.Role of AKT signaling in DNA repair and clinical response to cancer therapy.Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma.Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1.Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.A TORC2-Akt Feed-Forward Topology Underlies HER3 Resiliency in HER2-Amplified Cancers.Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.Signaling mechanisms regulating myelination in the central nervous system.PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.The regulation of microRNA expression by DNA methylation in hepatocellular carcinoma.PHLPPing through history: a decade in the life of PHLPP phosphatases.Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells.Antitumor effects of rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy.Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells.The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapyTranscription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells.Biochemical and cellular properties of insulin receptor signalling.The impact of phosphatases on proliferative and survival signaling in cancer.
P2860
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P2860
mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@ast
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@en
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@nl
type
label
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@ast
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@en
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@nl
prefLabel
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@ast
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@en
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@nl
P2093
P2860
P356
P1476
mTOR-dependent regulation of P ...... n sensitivity in cancer cells.
@en
P2093
Jianyu Liu
Payton D Stevens
Tianyan Gao
P2860
P304
P356
10.1074/JBC.M110.183087
P407
P577
2010-12-22T00:00:00Z