Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
about
Targeting Cell Survival Proteins for Cancer Cell DeathBcl-2 antagonists: a proof of concept for CLL therapyTargeting the Bcl-2 family for cancer therapyDesign of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New ScaffoldPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approachesInhibitory activity of apogossypol in human prostate cancer in vitro and in vivoInhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancerInhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.Recent advances in gossypol derivatives and analogs: a chemistry and biology view.An optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic bcl-2 family proteins.B-cell lymphoma 2 inhibitor ABT-737 induces Beclin1- and reactive oxygen species-dependent autophagy in Adriamycin-resistant human hepatocellular carcinoma cells.Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.Substituted indole Mcl-1 inhibitors: a patent evaluation (WO2015148854A1).
P2860
Q26765447-AC0AFACF-5B84-48F8-9296-07C755A2E74FQ26823996-1D49D0F4-92CF-4EA9-8366-0EB25DE7301CQ26866936-691FDC77-AACF-479E-B46A-5B48672CD601Q27678209-4AE88BAF-38B0-4906-ADF3-9926A4E35390Q28085240-9C6604B3-48E7-4CF9-B5A7-B33FA58B5FD1Q28540187-D641E238-0D79-4949-A1A6-2CE7E835D01FQ35387996-8C87BCEC-A84B-41E7-9439-831E20FEF22FQ35859229-B7506AFD-35E8-442B-AC2E-BFDA7B28BA56Q35876252-C2840067-B5A6-4D28-8B7C-3E383E5CCD42Q36172754-4BD7FB49-1077-4EF5-8755-68975C5D1D0DQ36541458-14F9BD77-C060-4D00-80AC-6466F239A04CQ36801115-B9E9EC9A-F591-40A9-B406-944E4431BB2FQ37073671-B5C5BF04-C5F2-4D18-9913-B7A5D827057FQ38151753-80A1D0DF-AD75-44E9-B4FD-E8748DDD8B46Q38655357-853DD32E-1937-4241-B0A7-E05364A520F7Q39614305-F8F60075-2C94-4030-966E-C089E72978FBQ46395032-33717063-AE85-4E47-B079-B9A02F9DF21EQ47167285-A18FBBC0-1CCD-4144-B609-45EC8F05D929Q51456092-638F0182-0CBF-4CFB-B700-7FD6204C94B0
P2860
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@ast
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@en
Synthesis and biological evalu ...... tic B-cell lymphoma/leukemia-2
@nl
type
label
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@ast
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@en
Synthesis and biological evalu ...... tic B-cell lymphoma/leukemia-2
@nl
prefLabel
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@ast
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@en
Synthesis and biological evalu ...... tic B-cell lymphoma/leukemia-2
@nl
P2093
P2860
P356
P1476
Synthesis and biological evalu ...... emia-2 (Bcl-2) family proteins
@en
P2093
Dayong Zhai
Jason Cellitti
John C Reed
John L Stebbins
Maurizio Pellecchia
Michele F Rega
Russell Dahl
P2860
P304
P356
10.1021/JM100746Q
P407
P577
2010-10-29T00:00:00Z