Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.
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Mthfs is an Essential Gene in Mice and a Component of the PurinosomeReduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfurationDisruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesisNuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiencyMthfd1 is a modifier of chemically induced intestinal carcinogenesis.Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNASerine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white malesmiR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectivelyFolate and colorectal cancer in rodents: a model of DNA repair deficiency.Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice.Dietary folic acid protects against genotoxicity in the red blood cells of mice.Targeting nuclear thymidylate biosynthesis.The Roles of SUMO in Metabolic Regulation.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.
P2860
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P2860
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
@zh-hk
2011年論文
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2011年論文
@zh-tw
2011年论文
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name
Shmt1 heterozygosity impairs f ...... acity and modifies risk of Apc
@nl
Shmt1 heterozygosity impairs f ...... diated intestinal cancer risk.
@ast
Shmt1 heterozygosity impairs f ...... diated intestinal cancer risk.
@en
type
label
Shmt1 heterozygosity impairs f ...... acity and modifies risk of Apc
@nl
Shmt1 heterozygosity impairs f ...... diated intestinal cancer risk.
@ast
Shmt1 heterozygosity impairs f ...... diated intestinal cancer risk.
@en
prefLabel
Shmt1 heterozygosity impairs f ...... acity and modifies risk of Apc
@nl
Shmt1 heterozygosity impairs f ...... diated intestinal cancer risk.
@ast
Shmt1 heterozygosity impairs f ...... diated intestinal cancer risk.
@en
P2093
P2860
P1433
P1476
Shmt1 heterozygosity impairs f ...... ediated intestinal cancer risk
@en
P2093
Amanda J Macfarlane
Cheryll A Perry
David M Lin
Patrick J Stover
P2860
P304
P356
10.1158/0008-5472.CAN-10-1886
P407
P577
2011-03-01T00:00:00Z