Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.
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PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridgeStructural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complexDiscovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate libraryThe Schizosaccharomyces pombe GPI8 gene complements a Saccharomyces cerevisiae GPI8 anchoring mutant.Post-translational GPI lipid anchor modification of proteins in kingdoms of life: analysis of protein sequence data from complete genomes.Major surface protease of trypanosomatids: one size fits all?Secretory pathway of trypanosomatid parasites.Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.Glycosyl phosphatidylinositol-anchored proteins in chemosensory signaling: antisense manipulation of Paramecium tetraurelia PIG-A gene expression.GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunitsGlycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sicknessProtein turnover and differentiation in Leishmania.Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review].The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi.Biosynthesis of glycosylphosphatidylinositol is essential to the survival of the protozoan parasite Toxoplasma gondii.Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins.Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein.Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system.Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring.Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites.Role of hexosamine biosynthesis in Leishmania growth and virulence.Sigma 1- and mu 1-Adaptin homologues of Leishmania mexicana are required for parasite survival in the infected host.The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies.SETH1 and SETH2, two components of the glycosylphosphatidylinositol anchor biosynthetic pathway, are required for pollen germination and tube growth in Arabidopsis.The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria
P2860
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P2860
Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.
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2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Leishmania mexicana mutants la ...... ions of GPI-anchored proteins.
@ast
Leishmania mexicana mutants la ...... ions of GPI-anchored proteins.
@en
Leishmania mexicana mutants lacking glycosylphosphatidylinositol
@nl
type
label
Leishmania mexicana mutants la ...... ions of GPI-anchored proteins.
@ast
Leishmania mexicana mutants la ...... ions of GPI-anchored proteins.
@en
Leishmania mexicana mutants lacking glycosylphosphatidylinositol
@nl
prefLabel
Leishmania mexicana mutants la ...... ions of GPI-anchored proteins.
@ast
Leishmania mexicana mutants la ...... ions of GPI-anchored proteins.
@en
Leishmania mexicana mutants lacking glycosylphosphatidylinositol
@nl
P2093
P2860
P921
P356
P1476
Leishmania mexicana mutants la ...... tions of GPI-anchored proteins
@en
P2093
G H Coombs
J D Hilley
J L Zawadzki
M J McConville
P2860
P304
P356
10.1091/MBC.11.4.1183
P577
2000-04-01T00:00:00Z