A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
about
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic functionMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairMre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityTargeting DNA Replication Stress for Cancer TherapyCollision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' AdductsDNA repair targeted therapy: The past or future of cancer treatment?Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerNucleases in homologous recombination as targets for cancer therapyChemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingDNA double-strand break repair pathway choice and cancerABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease ActivitiesImproving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assaysA Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous RecombinationPI3K-independent AKT activation in cancers: a treasure trove for novel therapeuticsHomology and enzymatic requirements of microhomology-dependent alternative end joiningSite-specific DICER and DROSHA RNA products control the DNA-damage responseAn evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic developmentDeregulation of DNA double-strand break repair in multiple myeloma: implications for genome stabilityThe MRN-CtIP pathway is required for metaphase chromosome alignment.Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMA distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint.Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.DNA damage response during mouse oocyte maturation.RAD51 interconnects between DNA replication, DNA repair and immunity.Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival.A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.Sequence conversion by single strand oligonucleotide donors via non-homologous end joining in mammalian cellsCdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repairSelective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).The MRN complex in double-strand break repair and telomere maintenance.Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidyRI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cellsRecruitment and retention dynamics of RECQL5 at DNA double strand break sites.The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells.Targeting abnormal DNA double strand break repair in cancer
P2860
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P2860
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@ast
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@en
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@nl
type
label
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@ast
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@en
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@nl
prefLabel
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@ast
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@en
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@nl
P2093
P2860
P356
P1476
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
@en
P2093
Ami P Modi
Aude Dupré
Jean Gautier
Ji-Hoon Lee
Levy Kopelovich
Louise Boyer-Chatenet
Maria Jasin
Matthew L Nicolette
Richard Baer
Rose M Sattler
P2860
P2888
P304
P356
10.1038/NCHEMBIO.63
P577
2008-01-06T00:00:00Z
P5875
P6179
1038979858