Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
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Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityAdenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensingThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesThe Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingSae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairEXD2 promotes homologous recombination by facilitating DNA end resectionRAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Ancient and recent adaptive evolution of primate non-homologous end joining genesRole of mammalian Mre11 in classical and alternative nonhomologous end joiningATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.An interaction between the Walker A and D-loop motifs is critical to ATP hydrolysis and cooperativity in bacteriophage T4 Rad50Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaksThe SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.Biochemical characterization of bacteriophage T4 Mre11-Rad50 complexThe Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forksA forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complexCorrect end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function inChromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining MechanismDNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous RecombinationDemonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activityConstitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapyMolecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complexAtaxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombinationSharpening the ends for repair: mechanisms and regulation of DNA resection.Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapyVisualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.ATM protein kinase: the linchpin of cellular defenses to stress.
P2860
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P2860
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@ast
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@en
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@nl
type
label
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@ast
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@en
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@nl
prefLabel
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@ast
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@en
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@nl
P2093
P2860
P3181
P1433
P1476
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
@en
P2093
Angela Chan
Aude Dupré
Ben B Hopkins
Bettina Lengsfeld
Jean Gautier
Ji-Hoon Lee
Tanya T Paull
Venugopal Bhaskara
Virginia Zakian
Xiaoming Zhang
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2007.01.028
P407
P577
2007-03-09T00:00:00Z