about
The Mediator subunit MDT-15 confers metabolic adaptation to ingested materialThe evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsHighly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic healthNuclear Receptors, RXR, and the Big BangRole of pregnane X receptor in chemotherapeutic treatmentModulation of xenobiotic receptors by steroidsPhenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat liversUnfolding of the C-Terminal Domain of the J-Protein Zuo1 Releases Autoinhibition and Activates Pdr1-Dependent TranscriptionInsights into CYP2B6-mediated drug-drug interactionsPeroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzymeSource-Related Effects of Wastewater on Transcription Factor (AhR, CAR and PXR)-Mediated Induction of Gene Expression in Cultured Rat Hepatocytes and Their Association with the Prevalence of Antimicrobial-Resistant Escherichia coliHomeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd miceAlterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactionsEvolution and medicine: the long reach of "Dr. Darwin"Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse OutcomesConstitutive Androstane Receptor PathwayExploration of the conformational landscape in pregnane X receptor reveals a new binding pocketDynamic regulation of Drosophila nuclear receptor activity in vivo.Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cellsEvaluation of CYP3A-mediated drug-drug interactions with romidepsin in patients with advanced cancer.The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeuticsActivation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.Pregnane X receptor and drug-induced liver injury.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cellsPregnane X receptor-mediated induction of Cyp3a by black cohosh.Cytochrome P450 and xenobiotic receptor humanized mice.Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.
P2860
Q21145049-A417C48C-DE43-4C94-955B-019A856E9ED3Q24804626-6E750469-35CE-4E59-86E1-2D3926D07EACQ24810893-0F947963-931A-4500-82A6-33B514F0CFFEQ26765492-7BF3E964-90EC-4B7B-ACA8-D446FF82D270Q26821789-8F8180CE-CCC8-4A27-B810-462E96EB3BFFQ26827398-A2A7D316-AE7C-4B1B-BAB2-53C15A5648EBQ27009230-AC521891-B148-4A42-95EE-985C417E4B1EQ27304855-3820181F-FF44-4BCC-9112-18C3B23ABC4FQ27674244-12D5F928-C422-41CC-BBB6-E6B2DB7EA68FQ28078857-F63940BF-4C9C-438D-B25D-C9115998964EQ28179772-1E421A65-86B1-41B3-A49B-5844AB66D6EAQ28389019-66A6EB25-18EE-4E42-869A-4D351FC563D8Q28508537-358FECBC-0865-436E-9E0E-452C6B6B8BD8Q28710150-6CD9B356-F239-496B-B70F-E913A1F86D69Q28762889-84B20229-CB07-42FF-AC4E-C9101FA70F47Q28830901-A951362C-1C5A-47EF-BA1C-FC5F1D6AFAE9Q30151266-5F3A5789-B059-4B56-9428-D3B216D3C37BQ30391745-EAB795CE-9695-4CD5-933F-B111C90CFAC3Q33254273-1F6BE88A-D51F-4F44-B066-BAB684DCEE50Q33397613-C4CC6216-5276-4328-AF07-188B81114461Q33423486-5F8D191E-927F-4A44-9651-1E812F6B1900Q33577156-61548399-8DC0-4582-855A-E4E18B87B377Q33726321-7F702396-CB02-4E07-80DB-826A26937B07Q33728760-30B180A6-4857-4D13-A3FA-95EBCE74A97FQ33756500-4A49AAF4-F47C-4A85-8042-15A70B94ED39Q33799970-7D5E6722-B069-4DF0-9A29-84835FF98D01Q33859400-7584DCFE-03AB-4A2D-8448-BED581E79A8BQ34115001-936B756D-9195-437B-833F-60654062E4C0Q34132197-AB121487-FE97-4956-B4B5-91648796C918Q34345049-7B3453D2-7F21-4B8C-9117-8A246DD7B158Q34349336-0AAA6519-0BD0-4FB7-8F81-27841BBC18ABQ34359979-ECF565D7-3CBB-4CC5-BBCF-23545877B4B5Q34396986-4F20DC43-57F0-4977-A8CE-59B9DFF1D67AQ34482267-56A863D4-77AF-418B-8027-227C9F05AD14Q34545343-E9F860E3-D4AB-45F6-87C0-44AD7A08CA27Q34614106-216B4595-EAC3-4F92-B49D-AED08B8889EAQ34692352-3EC25A92-1561-44C8-B217-33B518497366Q35014430-4BB852C3-AB47-4D81-9286-C82464C86E40Q35049887-DCFE2789-E63E-4C98-9124-F361C3D73ED2Q35148413-C13D1A2A-29CD-49E7-BE3C-CF0BBA79E2D4
P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
PXR, CAR and drug metabolism.
@ast
PXR, CAR and drug metabolism.
@en
PXR, CAR and drug metabolism.
@nl
type
label
PXR, CAR and drug metabolism.
@ast
PXR, CAR and drug metabolism.
@en
PXR, CAR and drug metabolism.
@nl
prefLabel
PXR, CAR and drug metabolism.
@ast
PXR, CAR and drug metabolism.
@en
PXR, CAR and drug metabolism.
@nl
P356
P1476
PXR, CAR and drug metabolism.
@en
P2093
Steven A Kliewer
Timothy M Willson
P2888
P304
P356
10.1038/NRD753
P577
2002-04-01T00:00:00Z