Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. - Wikidata - awgldk - TriplyDB

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

http://www.wikidata.org/entity/Q33728760

about

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment Role of pregnane X receptor in chemotherapeutic treatment Splice isoforms as therapeutic targets for colorectal cancer PXR variants: the impact on drug metabolism and therapeutic responses Irinotecan pharmacogenomics Transcriptional regulation of mouse PXR gene: an interplay of transregulatory factors Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.Species-associated differences in the inhibition of propofol glucuronidation by magnolol Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects Overcoming drug resistance by regulating nuclear receptors.In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.PXR antagonists and implication in drug metabolism.Expression of the PXR gene in various types of cancer and drug resistance Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.Pregnane X Receptor and Cancer: Context-Specificity is Key.Pregnane X-receptor promotes stem cell-mediated colon cancer relapse Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.A new frontier in personalized cancer therapy: mapping molecular changes.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Pharmacogenetics of the nuclear hormone receptors: the missing link between environment and drug effects?Epigenetic perspectives on cancer chemotherapy response.Effect of pregnane X receptor expression on drug resistance in breast cancer.Epigenetic alternations and cancer chemotherapy response.Nuclear receptors and drug metabolism for the personalization of cancer therapy.In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine.Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.Mir-148a improves response to chemotherapy in sensitive and resistant oesophageal adenocarcinoma and squamous cell carcinoma cells.Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.Expression of membrane drug efflux transporters in the sigmoid colon of HIV-infected and uninfected men.Calpain 2-dependent IκBα degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts.MALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids.Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients.Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.

P2860

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P2860

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

http://www.wikidata.org/entity/Q33728760

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Pregnane X Receptor (PXR) expr ...... nhanced SN-38 glucuronidation.

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Pregnane X Receptor (PXR) expr ...... nhanced SN-38 glucuronidation.

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type

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Pregnane X Receptor (PXR) expr ...... nhanced SN-38 glucuronidation.

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Pregnane X Receptor (PXR) expr ...... nhanced SN-38 glucuronidation.

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Pregnane X Receptor (PXR) expr ...... nhanced SN-38 glucuronidation.

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Pregnane X Receptor (PXR) expr ...... nhanced SN-38 glucuronidation.

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Molecular Cancer

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Pregnane X Receptor (PXR) expr ...... enhanced SN-38 glucuronidation

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Alexandre Evrard

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Benjamin Lallemant

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Caroline Bonnans

http://www.w3.org/2001/XMLSchema#string

Caroline Raynal

http://www.w3.org/2001/XMLSchema#string

Cyril Breuker

http://www.w3.org/2001/XMLSchema#string

Dominique Joubert

http://www.w3.org/2001/XMLSchema#string

Frédéric Hollande

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Géraldine Leguelinel

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Jean-Paul Brouillet

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Jovana Kantar

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P2860

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene.

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

Irinotecan chemotherapy during valproic acid treatment: pharmacokinetic interaction and hepatotoxicity.

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

PXR, CAR and drug metabolism.

Lessons learned from the irinotecan metabolic pathway.

Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.

P2888

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46

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scholarly article

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10.1186/1476-4598-9-46

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9

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Jean Marc Pascussi

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2010-03-02T00:00:00Z

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41668661

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1048226787

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20196838

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colorectal cancer

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2838814

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