Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. - Wikidata - awgldk - TriplyDB

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.

http://www.wikidata.org/entity/Q34759496

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The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium The new collagen gene COL27A1 contains SOX9-responsive enhancer elements Reduced sox9 function promotes heart valve calcification phenotypes in vivo The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters.Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration.SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc.Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism.Morphogenetic and regulatory mechanisms during developmental chondrogenesis: new paradigms for cartilage tissue engineering.Transcriptional control of mesenchymal stem cell differentiation.Unraveling the transcriptional regulatory machinery in chondrogenesis.ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity.Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer.Sox9-dependent transcriptional regulation of the proprotein convertase furin.A Col9a1 enhancer element activated by two interdependent SOX9 dimers.Computational identification and functional validation of regulatory motifs in cartilage-expressed genes.Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site.Highly conserved proximal promoter element harbouring paired Sox9-binding sites contributes to the tissue- and developmental stage-specific activity of the matrilin-1 gene A novel retinoic acid-response element requires an enhancer element mediator for transcriptional activation.Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage.SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation.Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements.

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Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.

http://www.wikidata.org/entity/Q34759496

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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name

Adjacent DNA sequences modulat ...... te-specific enhancer elements.

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Adjacent DNA sequences modulat ...... te-specific enhancer elements.

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Adjacent DNA sequences modulat ...... te-specific enhancer elements.

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Adjacent DNA sequences modulat ...... te-specific enhancer elements.

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Adjacent DNA sequences modulat ...... te-specific enhancer elements.

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Benoit de Crombrugghe

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Gwen C Miller

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Jennifer L Potter

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L Daniel Holsinger

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Laura C Bridgewater

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Marlan D Walker

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Reuben K Chen

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Sandra McKinney

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Todd L Jackson

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Trevor A Ellison

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P2860

Autosomal recessive disorder otospondylomegaepiphyseal dysplasia is associated with loss-of-function mutations in the COL11A2 gene.

Oto- spondylo-megaepiphyseal dysplasia (OSMED): clinical description of three patients homozygous for a missense mutation in the COL11A2 gene

Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

From head to toes: the multiple facets of Sox proteins

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Pairing SOX off: with partners in the regulation of embryonic development

SOX9 directly regulates the type-II collagen gene

Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

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1541-1553

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10.1093/NAR/GKG230

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5

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31

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277470993

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12595563

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