Redox platforms in cancer drug discovery and development.
about
Protein glutathionylation in cardiovascular diseasesChemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer CellsPhase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphomaCellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-rasReversible and irreversible protein glutathionylation: biological and clinical aspects.Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytesThe mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cellsD-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosisPleiotropic functions of glutathione S-transferase PCellular redox pathways as a therapeutic target in the treatment of cancer.Mitochondria and redox homoeostasis as chemotherapeutic targets.Investigation of the cytotoxic implications of metal chelators against melanoma and approaches to improve the cytotoxicity profiles of metal coordinating agents.Increased generation of intracellular reactive oxygen species initiates selective cytotoxicity against the MCF-7 cell line resultant from redox active combination therapy using copper-thiosemicarbazone complexes.(-)-Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies.Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma.Possible modulating impact of glutathione disulfide mimetic on physiological changes in irradiated rats.Modeling the acid-base properties of glutathione in different ionic media, with particular reference to natural waters and biological fluids.
P2860
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P2860
Redox platforms in cancer drug discovery and development.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Redox platforms in cancer drug discovery and development.
@ast
Redox platforms in cancer drug discovery and development.
@en
Redox platforms in cancer drug discovery and development.
@nl
type
label
Redox platforms in cancer drug discovery and development.
@ast
Redox platforms in cancer drug discovery and development.
@en
Redox platforms in cancer drug discovery and development.
@nl
prefLabel
Redox platforms in cancer drug discovery and development.
@ast
Redox platforms in cancer drug discovery and development.
@en
Redox platforms in cancer drug discovery and development.
@nl
P2860
P1476
Redox platforms in cancer drug discovery and development.
@en
P2093
Danyelle M Townsend
Kenneth D Tew
P2860
P304
P356
10.1016/J.CBPA.2010.10.016
P577
2010-11-11T00:00:00Z