Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.
about
Computer-aided Molecular Design of Compounds Targeting Histone Modifying EnzymesKDM1 class flavin-dependent protein lysine demethylasesNew insights into the kinetic target-guided synthesis of protein ligands.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway.Inhibitors of Protein Methyltransferases and Demethylases.Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates.Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architecturesSensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors.Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen.Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells.
P2860
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P2860
Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@ast
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@en
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@nl
type
label
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@ast
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@en
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@nl
prefLabel
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@ast
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@en
Lysine-specific demethylase 1- ...... geted drug delivery mechanism.
@nl
P2093
P2860
P356
P1476
Lysine-specific demethylase 1- ...... rgeted drug delivery mechanism
@en
P2093
Daisuke Ogasawara
Hidehiko Nakagawa
Hiroki Tsumoto
Kiyoshi Fukuhara
Koshiki Mino
Makoto Hasegawa
Naoki Miyata
Ryuzo Sasaki
Taeko Kakizawa
Takayoshi Suzuki
P2860
P304
P356
10.1002/ANIE.201303999
P407
P577
2013-07-03T00:00:00Z