DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. - Wikidata - awgldk - TriplyDB

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

http://www.wikidata.org/entity/Q34807677

about

Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.Newly identified aspects of tumor suppression by RB Molecular mechanisms underlying RB protein function Mechanisms of disseminated cancer cell dormancy: an awakening field E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2 The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.MicroRNA-146a affects the chemotherapeutic sensitivity and prognosis of advanced gastric cancer through the regulation of LIN52 The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome.Loss of the mammalian DREAM complex deregulates chondrocyte proliferation The normal function of the cancer kinase Mirk/dyrk1B is to reduce reactive oxygen species p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes.Mirk kinase inhibition targets ovarian cancer ascites.The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.The DREAM complex: master coordinator of cell cycle-dependent gene expression.Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells.A kinase shRNA screen links LATS2 and the pRB tumor suppressor Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.Structural mechanisms of DREAM complex assembly and regulation.DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3 Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma Senescence and quiescence induced compromised function in cultured macrophages Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence.Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition.Inhibition of DYRK1A Stimulates Human β-Cell Proliferation Human papillomavirus infections: warts or cancer?

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P2860

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

http://www.wikidata.org/entity/Q34807677

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@ast

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@en

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@nl

type

label

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@ast

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@en

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@nl

prefLabel

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@ast

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@en

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@nl

P1433

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P1433

Genes & Development

P1476

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

@en

P2093

James A DeCaprio

http://www.w3.org/2001/XMLSchema#string

Selene K Swanson

http://www.w3.org/2001/XMLSchema#string

P2860

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

Cell cycle, CDKs and cancer: a changing paradigm

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis

Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

The selectivity of protein kinase inhibitors: a further update

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

P304

801-813

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P31

scholarly article

P356

10.1101/GAD.2034211

http://www.w3.org/2001/XMLSchema#string

P433

8

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P478

25

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P50

Laurence Florens

Michael P. Washburn

Larisa Litovchick

P577

2011-04-01T00:00:00Z

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P5875

51056438

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P698

21498570

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P932

3078706

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