Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. - Wikidata - awgldk - TriplyDB

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

http://www.wikidata.org/entity/Q34827173

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Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption.Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptide Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum Crystal structure of a human GABAA receptor Principles of activation and permeation in an anion-selective Cys-loop receptor A locally closed conformation of a bacterial pentameric proton-gated ion channel Targeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.Positive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596 Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Changes in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes Function of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.

P2860

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P2860

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

http://www.wikidata.org/entity/Q34827173

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

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2008年論文

@zh-tw

2008年论文

@wuu

name

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@ast

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@en

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@nl

type

label

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

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Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@en

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@nl

prefLabel

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@ast

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@en

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@nl

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PNAS.0804372105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Potentiation of alpha7 nicotin ...... allosteric transmembrane site.

@en

P2093

Alison S Walker

http://www.w3.org/2001/XMLSchema#string

Emanuele Sher

http://www.w3.org/2001/XMLSchema#string

Gareth T Young

http://www.w3.org/2001/XMLSchema#string

Neil S Millar

http://www.w3.org/2001/XMLSchema#string

Ruud Zwart

http://www.w3.org/2001/XMLSchema#string

P2860

Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

Structure and gating mechanism of the acetylcholine receptor pore

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

A semiempirical free energy force field with charge-based desolvation

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.

Allosteric modulation of nicotinic acetylcholine receptors.

Allosteric mechanisms of signal transduction.

Neuronal nicotinic acetylcholine receptors: from the gene to the disease.

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14686-14691

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scholarly article

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10.1073/PNAS.0804372105

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38

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105

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2008-09-12T00:00:00Z

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18791069

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P921

transmembrane protein

P932

2535569

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