Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
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Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption.Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptideIon channels gated by acetylcholine and serotonin: structures, biology, and drug discoveryα7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimumCrystal structure of a human GABAA receptorPrinciples of activation and permeation in an anion-selective Cys-loop receptorA locally closed conformation of a bacterial pentameric proton-gated ion channelTargeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptorsChemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRsPharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived NeuronsSimilarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological ProfileThe α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membranePhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.Positive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperaturesPhysiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Changes in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesFunction of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane siteAn allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrusPositive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.
P2860
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P2860
Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@ast
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@en
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@nl
type
label
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@ast
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@en
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@nl
prefLabel
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@ast
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@en
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@nl
P2093
P2860
P356
P1476
Potentiation of alpha7 nicotin ...... allosteric transmembrane site.
@en
P2093
Alison S Walker
Emanuele Sher
Gareth T Young
Neil S Millar
Ruud Zwart
P2860
P304
14686-14691
P356
10.1073/PNAS.0804372105
P407
P577
2008-09-12T00:00:00Z