An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.
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α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeperTethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.The effective opening of nicotinic acetylcholine receptors with single agonist binding sitesPositive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.Classifying neuronal subclasses of the cerebellum through constellation pharmacology.Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational BiomarkerMechanism of Allosteric Modulation of the Cys-loop Receptors.Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.
P2860
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P2860
An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
An allosteric modulator of alp ...... those caused by acetylcholine.
@ast
An allosteric modulator of alp ...... those caused by acetylcholine.
@en
An allosteric modulator of alp ...... those caused by acetylcholine.
@nl
type
label
An allosteric modulator of alp ...... those caused by acetylcholine.
@ast
An allosteric modulator of alp ...... those caused by acetylcholine.
@en
An allosteric modulator of alp ...... those caused by acetylcholine.
@nl
prefLabel
An allosteric modulator of alp ...... those caused by acetylcholine.
@ast
An allosteric modulator of alp ...... those caused by acetylcholine.
@en
An allosteric modulator of alp ...... those caused by acetylcholine.
@nl
P2093
P2860
P356
P1476
An allosteric modulator of alp ...... those caused by acetylcholine.
@en
P2093
James T McLaughlin
Jennifer A See
Robert L Rosenberg
Sean C Barron
Vanessa L Richards
P2860
P304
P356
10.1124/MOL.109.056226
P577
2009-05-01T00:00:00Z