about
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombinationA chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesisA high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localizationTumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathybeta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulationInhibition of the sodium/potassium ATPase impairs N-glycan expression and function.High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies.Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domainDigitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks.A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2KRB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy.Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitorPI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer.A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilitiesExcess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.MicroRNA implications across neurodevelopment and neuropathology.PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiaeIbrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanismInhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Alessandro Datti
@ast
Alessandro Datti
@en
Alessandro Datti
@es
type
label
Alessandro Datti
@ast
Alessandro Datti
@en
Alessandro Datti
@es
prefLabel
Alessandro Datti
@ast
Alessandro Datti
@en
Alessandro Datti
@es
P106
P1153
6603681192
P21
P31
P496
0000-0001-6824-7382