Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells. - Wikidata - awgldk - TriplyDB

Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.

Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.

http://www.wikidata.org/entity/Q34921343

about

Immune surveillance for ERAAP dysfunction Antigenic peptide trimming by ER aminopeptidases--insights from structural studies Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum Pathways of antigen processing.ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1 Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite.The first step of peptide selection in antigen presentation by MHC class I molecules.Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2 Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1 ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.Don't mess with ERAAP!Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.Post-proteasomal and proteasome-independent generation of MHC class I ligands.Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases.ERAP1 in the pathogenesis of ankylosing spondylitis.The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.Sequence-specific alterations of epitope production by HIV protease inhibitors.Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation.The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses.Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.ERAAP modulation: A possible novel strategy for cancer immunotherapy?Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection.Ranking the contribution of ankylosing spondylitis-associated ERAP1 polymorphisms to shaping the HLA-B*27 peptidome.The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection

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P2860

Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.

http://www.wikidata.org/entity/Q34921343

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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type

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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prefLabel

Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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JIMMUNOL.0903712

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Journal of Immunology

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Endoplasmic reticulum aminopep ...... rmal and virus-infected cells.

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David K Crockett

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Frédéric Delebecque

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Hernando Escobar

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Julio C Delgado

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Nilabh Shastri

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Niranjana A Nagarajan

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Takayuki Kanaseki

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P2860

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex

Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice

Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules.

Large scale mass spectrometric profiling of peptides eluted from HLA molecules reveals N-terminal-extended peptide motifs.

P304

3033-3042

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scholarly article

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10.4049/JIMMUNOL.0903712

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6

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184

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David H. Raulet

Nicolas Blanchard

Eduardo Reyes-Vargas

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2010-02-19T00:00:00Z

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41509776

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20173027

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endoplasmic reticulum

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3087292

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