Identification of a pH sensor in the furin propeptide that regulates enzyme activation - Wikidata - awgldk - TriplyDB

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

http://www.wikidata.org/entity/Q34940590

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Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets Nonbonded terms extrapolated from nonlocal knowledge-based energy functions improve error detection in near-native protein structure models.Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.Functional analysis of the cucumisin propeptide as a potent inhibitor of its mature enzyme.Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.Modeling the step of endosomal escape during cell infection by a nonenveloped virus Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin.Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.The subcellular distribution of calnexin is mediated by PACS-2 The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin.Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation.Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors.Subtilases - versatile tools for protein turnover, plant development, and interactions with the environment.The metalloprotease of Listeria monocytogenes is regulated by pH.The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.PCSK1 Variants and Human Obesity.Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.Ebola virus envelope glycoprotein derived peptide in human Furin-bound state: computational studies.A non-catalytic histidine residue influences the function of the metalloprotease of Listeria monocytogenes.An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations.Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.Characterization of the glutamyl endopeptidase from Staphylococcus aureus expressed in Escherichia coli.The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases

P2860

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P2860

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

http://www.wikidata.org/entity/Q34940590

description

2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@ast

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@en

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@nl

type

label

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@ast

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@en

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@nl

prefLabel

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@ast

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@en

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

@en

P2093

Chien-Hui Hung

http://www.w3.org/2001/XMLSchema#string

Ezhilkani Subbian

http://www.w3.org/2001/XMLSchema#string

François Jean

http://www.w3.org/2001/XMLSchema#string

Gary Thomas

http://www.w3.org/2001/XMLSchema#string

Gregory K Scott

http://www.w3.org/2001/XMLSchema#string

Laurel Thomas

http://www.w3.org/2001/XMLSchema#string

Sean S Molloy

http://www.w3.org/2001/XMLSchema#string

Sylvain F Feliciangeli

http://www.w3.org/2001/XMLSchema#string

Ujwal Shinde

http://www.w3.org/2001/XMLSchema#string

P2860

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

Furin at the cutting edge: from protein traffic to embryogenesis and disease

SWISS-MODEL: An automated protein homology-modeling server

Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

The crystal structure of an autoprocessed Ser221Cys-subtilisin E-propeptide complex at 2.0 A resolution

Precursor processing by kex2/furin proteases

PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

P304

16108-16116

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scholarly article

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10.1074/JBC.M600760200

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P433

23

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P478

281

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P577

2006-04-06T00:00:00Z

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P698

16601116

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P932

4293020

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