Computational structure-based redesign of enzyme activity. - Wikidata - awgldk - TriplyDB

Computational structure-based redesign of enzyme activity.

Computational structure-based redesign of enzyme activity.

http://www.wikidata.org/entity/Q34948584

about

Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity Computational enzyme design approaches with significant biological outcomes: progress and challenges Computational design of a red fluorophore ligase for site-specific protein labeling in living cells Beyond directed evolution--semi-rational protein engineering and design Doing molecular biophysics: finding, naming, and picturing signal within complexity Predicting resistance mutations using protein design algorithms Structural Elucidation of the Bispecificity of A Domains as a Basis for Activating Non-natural Amino Acids Protein design using continuous rotamers Calculating ensemble averaged descriptions of protein rigidity without sampling Structure-guided deimmunization of therapeutic proteins Coupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand Specificity Protein folding and de novo protein design for biotechnological applications Protein side-chain modeling with a protein-dependent optimized rotamer library.Computational approaches for rational design of proteins with novel functionalities Antibody humanization by structure-based computational protein design.comets (Constrained Optimization of Multistate Energies by Tree Search): A Provable and Efficient Protein Design Algorithm to Optimize Binding Affinity and Specificity with Respect to Sequence.LUTE (Local Unpruned Tuple Expansion): Accurate Continuously Flexible Protein Design with General Energy Functions and Rigid Rotamer-Like Efficiency.Achievements and Challenges in Computational Protein Design.Parallel Computational Protein Design.Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data.Dead-end elimination with perturbations (DEEPer): a provable protein design algorithm with continuous sidechain and backbone flexibility.Conformational diversity and computational enzyme design Tradeoff between stability and multispecificity in the design of promiscuous proteins.Protein thermostability calculations using alchemical free energy simulations An efficient parallel algorithm for accelerating computational protein design.Optimization of combinatorial mutagenesis.Evolution: a guide to perturb protein function and networks Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.Protein loop closure using orientational restraints from NMR data An energy-based conformer library for side chain optimization: improved prediction and adjustable sampling.OSPREY: protein design with ensembles, flexibility, and provable algorithms.An automated flow for directed evolution based on detection of promiscuous scaffolds using spatial and electrostatic properties of catalytic residues.The role of local backrub motions in evolved and designed mutations Binding pocket optimization by computational protein design.Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo.Computational design of protein-small molecule interfaces.Computational design of affinity and specificity at protein-protein interfaces Protein design algorithms predict viable resistance to an experimental antifolate Structure-based design of combinatorial mutagenesis libraries

P2860

Q21145315-116588D5-8B5E-4EBE-94E1-5A102EB15F81 Q24273262-F7357527-EBE7-4511-B271-EF9791532E88 Q24564583-4DF7D78D-08B4-4E6D-B4EE-1EE42FC9FCC9 Q24604225-8E0741FB-D09C-42C9-8BD3-A7B3F90EF6FF Q24606699-D318B847-7753-4375-B5AF-A29E864598BB Q27663576-6E530A74-C366-48FC-BAF1-0B609D768775 Q27701084-7A254D7A-D12F-49F4-A308-6A62611FA2FA Q28478881-7EC6A640-B645-4511-A926-69D8A80CC6FB Q28481155-01C3E0B0-EB88-4965-8F6C-9E34A04BA796 Q28486242-42CF17B9-BAAD-4EAD-B1E2-3909AF88981E Q28914714-3B2A9EFE-6B7B-46E1-9F4D-60C576AE9B78 Q30355936-4D8036BF-EAF6-46C4-8BF4-E5FF338A0FCD Q30360147-70E16D7A-8ED8-48C1-A72B-31D96FD3C0EC Q30360853-B90D9328-9F22-458E-8284-CAC022BFFF54 Q30377654-0A40AA70-A7E3-45A3-AA42-C5039F46CAD0 Q30383489-30C2C881-C435-4EE0-9C27-0C695FCC0F6E Q30393514-7287F5EE-109B-4326-86F6-237076A42EC7 Q30395939-BF5B5B0C-8379-4881-A434-A9A2327D0676 Q30395958-7EFC2E7D-931C-4147-8EC9-CF7849C168C1 Q30404250-89523C3E-F4DF-4D36-A515-622282F80173 Q30407752-09376EED-ED17-4DD9-A28B-47C29B197493 Q30419532-7A78AC31-9518-4897-B500-D868E6FC0E89 Q30989118-F0960E80-0B9A-4E5E-B572-F5F780238D3C Q33521300-CB4323C4-B018-435C-9438-B6F4B99DEBD0 Q33581606-ABB0681F-C001-47CA-B23D-2C6BC82863D6 Q33760390-3BAE745A-1ED5-4E35-82D8-B5996F453016 Q34020780-24623D81-EE54-4D53-A55D-7C45603391D9 Q34047786-4D2FF627-3DB4-4BD0-B673-BF2252E204C8 Q34075820-2177D582-073B-4A60-A9CD-842E7C597B8A Q34097299-25C0ADBF-8389-4B20-A0C2-D56115370531 Q34265765-57522D6D-D922-454E-8C71-23255EAD940F Q34328545-B3D2C0C5-F615-427A-9A06-B71AF5004326 Q34343512-05650F52-DDB4-4DB2-91A8-70101C300657 Q34372287-81B3286A-640C-4864-98DA-538C478111F6 Q34540792-A68C5632-DEE3-406B-9DD6-F709064C7E32 Q34593860-ABAF0E1B-731E-4EF1-93FE-86E70D91956C Q34959454-286034F3-0864-44BC-8A51-ECEFB6230BE4 Q34995050-B84BA103-D626-4C8B-AF7B-55468FC567A8 Q35031482-144E9E32-E0EC-41D8-8061-F805BF4B818A Q35547152-C680CCB3-ACBD-47D4-A83D-FCFCF0BD9804

P2860

Computational structure-based redesign of enzyme activity.

http://www.wikidata.org/entity/Q34948584

description

2009 nî lūn-bûn

@nan

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Computational structure-based redesign of enzyme activity.

@ast

Computational structure-based redesign of enzyme activity.

@en

Computational structure-based redesign of enzyme activity.

@nl

type

label

Computational structure-based redesign of enzyme activity.

@ast

Computational structure-based redesign of enzyme activity.

@en

Computational structure-based redesign of enzyme activity.

@nl

prefLabel

Computational structure-based redesign of enzyme activity.

@ast

Computational structure-based redesign of enzyme activity.

@en

Computational structure-based redesign of enzyme activity.

@nl

P1433

Q34948584-F3C369BB-201C-4E53-BA00-9B2A71CF0EB4

P1476

Q34948584-045EE1A8-231B-4A11-AC28-0F0A1E0C5ED6

P2093

Q34948584-134735E4-C87C-4271-B905-FDAB32A676C3

Q34948584-8F954FC7-F23D-4A8C-B4CF-6296B283D95F

Q34948584-96459FA8-C55E-4112-B4E3-5DDB6BFFE359

Q34948584-D4B7C7ED-69AC-40C3-86FF-ED5BBD50B005

P2860

Q34948584-0258A1B4-98E8-4A18-8A14-3116469F4036

Q34948584-050AE65C-9DD6-4D99-AA43-1693F90B4178

Q34948584-0C6D99E3-B10C-44EE-B072-55F7A78D981E

Q34948584-0FEF37AE-DF07-4A2A-9792-60650AF6FBAB

Q34948584-19D8A4A6-2B1E-4AEB-B0B4-D10040E0C1B1

Q34948584-2A5C7792-E7FE-4B12-A96F-908EF817A7E0

Q34948584-3050F5A8-81D3-4425-BFB5-DC282B405196

Q34948584-3B6E7023-06C3-494D-AD52-E8AD53E656F1

Q34948584-3C10317D-C3B0-4B4D-8E19-AB138817DFA7

Q34948584-3E32834A-8AA3-4269-81C4-7F2A524A3A3E

P304

Q34948584-70222098-9AEB-4BA8-B9A6-41BFE716C46A

P31

Q34948584-7F274BFC-2D30-46F0-BE2F-EFE91875981B

P356

Q34948584-F34DBD98-0C4D-419F-A379-01356733AF63

P407

Q34948584-B11553D9-39E4-4F85-8652-AF5FFC4649BB

P433

Q34948584-7798A15B-80F1-490E-9E79-53A4C92E5599

P478

Q34948584-A2A4E4C0-AE99-4385-8E43-34410BEC5262

P577

Q34948584-CE0FD95E-BD17-4BB4-BFD7-2EA2D0625E3A

P5875

Q34948584-89F32F38-EA8D-4E5E-B493-120504AF3181

P698

Q34948584-C83CB4EB-98A8-4C48-AD02-103C165BF883

P932

Q34948584-064E0E36-2396-4A52-8CAD-8FC7415FF92F

P356

PNAS.0900266106

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Computational structure-based redesign of enzyme activity.

@en

P2093

Amy C Anderson

http://www.w3.org/2001/XMLSchema#string

Bruce R Donald

http://www.w3.org/2001/XMLSchema#string

Cheng-Yu Chen

http://www.w3.org/2001/XMLSchema#string

Ivelin Georgiev

http://www.w3.org/2001/XMLSchema#string

P2860

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

De novo computational design of retro-aldol enzymes

Kemp elimination catalysts by computational enzyme design

De novo protein design: fully automated sequence selection

Effective energy function for proteins in solution

Directed evolution of enzyme catalysts

Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes

Backrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain prediction

The penultimate rotamer library

P304

3764-3769

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0900266106

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

106

http://www.w3.org/2001/XMLSchema#string

P577

2009-02-19T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

24026830

http://www.w3.org/2001/XMLSchema#string

P698

19228942

http://www.w3.org/2001/XMLSchema#string

P932

2645347

http://www.w3.org/2001/XMLSchema#string